Yamanouchi Pharmaceutical Company Ltd.

Hideya Matsuda

Toshinari Tamura

Masuo Murakami

Isao Yanagisawa

Kenichi Tomioka

Hidenori Iwamoto

Yoshio Ishii

Makoto Yoshida

Noriyoshi Inukai

Osamu Hasegawa

Tetsuya Shiozaki

A novel crystal form of N.sup..alpha. -[[(S)-4-oxo-2-azetidinyl]-carbonyl]-L-histidyl-L-prolinamide is provided and a process for preparing such crystals. The crystals provided by the present invention are the dihydrate form of the compound which exhibits a specific X-ray powder diffraction pattern, infared absorption spectrum and thermogravimetry-differential scanning calorimetry. The compound in its novel crystal form is useful in the treatment of consciousness disturbances and memory disorders.

Crystalline form III of N.sup..alpha. -[[(S)-4-oxo-2-azetidinyl]-carbonyl]-

Novel prostaglandin derivatives are provided having the formula: ##STR1## wherein A represents ##STR2## one of R.sub.3 and R.sub.4 represents a hydrogen atom and the other of them represents a lower alkyl group; one of R.sub.5 and R.sub.6 represents a hydrogen atom and the other of them represents a hydroxyl group; and one of R.sub.7 and R.sub.8 represents a hydrogen atom and the other of them represents a lower alkyl group. The compounds of this invention have excellent effects as prostaglandin E.sub.2 and prostaglandin F.sub.2.sub..alpha..

Novel prostaglandin derivatives

Growing community of inventors

Urawa, Japan

Hideya Matsuda