Fujisawa Pharmaceutical Company, Ltd.

Hidetsugu Murai

Masakuni Okuhara

Sumio Kiyoto

Masashi Hashimoto

Keiji Hemmi

Masanobu Kohsaka

Hiroshi Hatanaka

Shigehiro Takase

Seiji Hashimoto

Yasuhisa Tsurumi

Itsuo Uchida

Hiroshi Terano

Nobutaka Oohata

Motoaki Nishikawa

Kumiko Nitta

Anthraquinone compounds of the formula: ##STR1## wherein: R.sup.1 is hydrogen, hydroxy or acyloxy,

Anthraquinone derivatives and preparation thereof

This invention relates to new carboxylic acid derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen, lower alkyl or aryl, and pharmaceutically acceptable salt thereof which inhibit activity of DHP-I, to a process for preparing them and to an antibacterial composition comprising them and carbapenem antibiotics.

Carboxylic acid derivatives

The invention relates to a new compound, designated FR-68504. The compound has antitimor activities and is effective in the treatment of various tumors in both human beings and animals. There is also provided a process for preparing FR-68504 compound which comprises culturing a FR-68504 producing strain belonging to the genus Amauroascus in a nutrient medium. Pharmaceutical composition comprising FR-68504 as an active ingredient is also described.

Compound FR-68504, production thereof and use thereof

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Tsukuba, Japan

Hidetsugu Murai