Ube Industries, Inc.

Santen Pharmaceutical Co., Ltd.

Daiichi Sankyo Company, Limited

Santen Pharmaceuticalco., Ltd.

Hidetoshi Sunamoto

Masahiko Hagihara

Noriaki Iwase

Ken-ichi Komori

Kazutaka Kido

Hiroshi Nishida

Takeshi Matsugi

Tomio Kimura

Shigeru Ushiyama

Shigeyuki Kono

Yusuke Shiraishi

Yasuhiro Aga

Tadashi Nakajima

Masahiro Kojima

Satoshi Umezaki

Masakazu Hatano

Hideaki Hara

Sayaka Ogi

Kazuhiro Onuma

Takashi Matsushita

Makoto Okudo

Masayuki Tanaka

Tsuyoshi Nakamura

Hidenori Namiki

Yasunori Tsuzaki

Katsunori Takata

Koji Ito

Masaaki Matoyama

Akira Takama

Naoki Terasaka

Kenji Yoneda

Hiroyuki Setoguchi

Osamu Kikuchi

Tomokazu Fujimoto

Hayato Nishiyama

Akiko Shima

Kazunari Tsuboike

The present invention provides a compound represented by the general formula (Ia) or a pharmacologically acceptable salt thereof. In the general formula (Ia), two R moieties each independently represent a Calkyl group or the like; and R, Rand Reach independently represent an optionally substituted linear or branched Calkyl group. 

Substituted dihydropyrrolopyrazole derivative

Provided is a compound represented by formula (I) or a pharmacologically acceptable salt thereof: wherein Lis an optionally substituted Calkylene group or the like, Lis a single bond or the like, Lis a single bond or the like, R, R, and Rare each independently an optionally substituted Calkyl group or the like, Ris a hydrogen atom or the like, and Ris a hydrogen atom or the like.

Substituted dihydropyrrolopyrazole compound

The present invention provides a substituted pyridine compound or a pharmacologically acceptable salt thereof which has excellent CETP inhibition activity and is useful as a medicament. The present invention provides a compound represented by a general formula (I), wherein Ris H, optionally substituted alkyl, OH, optionally substituted alkoxy, alkylsulfonyl, optionally substituted amino, carboxy, optionally substituted carbonyl, CN, halogeno, optionally substituted phenyl, optionally substituted aromatic heterocyclyl, optionally substituted saturated heterocyclyl, optionally substituted saturated heterocyclyloxy or optionally substituted saturated heterocyclylcarbonyl, etc., and the like.

Substituted pyridine compound

A compound represented by formula (1) or salt thereof and a production intermediate thereof are created. The compound exhibited an excellent antioxidation action in a microsome lipid peroxidation measuring system using a rat liver microsome. Therefore, the compound or salt thereof is useful as an antioxidant. The present invention also provides use of a compound represented by the formula (1) or a pharmaceutically acceptable salt thereof for production of an antioxidant. 

Indazole derivative or salt thereof and production intermediate thereof, and antioxidant using same, and use of indazole derivative or salt thereof

A method for treating a disease in which Rho kinase is involved. The method is carried out by administering to a patient in need thereof a pharmaceutically effective amount of a compound of the following formula or a pharmaceutically acceptable salt thereof: 

Methods for treating a disease in which Rho kinase is involved

A method for treating a disease in which Rho kinase is involved. The method is carried out by administering to a patient in need thereof a pharmaceutically effective amount of a compound of the following formula or a pharmaceutically acceptable salt thereof: wherein the ring X is a benzene ring or a pyridine ring; Rand Rare hydrogen or alkyl or together form a cycloalkene ring; Ris hydrogen, substituted alkyl, unsubstituted alkenyl, carboxyl or an ester or an amide thereof, amino or a cyano; Ris hydrogen, hydroxyl, substituted or unsubstituted alkoxy, unsubstituted alkenyloxy, unsubstituted cycloalkyloxy, substituted or unsubstituted alkyl, unsubstituted alkenyl, unsubstituted cycloalkyl, amino, substituted or unsubstituted alkylamino, nitro, cyano or a monocyclic heterocycle; and Ris a halogen atom or a hydrogen atom.

An object of the present invention is to create a novel indazole derivative useful as a drug and to find a novel pharmacological action of the derivative. The compound of the present invention is represented by the formula [I] and has an excellent Rho kinase inhibiting action. In the formula, a ring X is a benzene ring or a pyridine ring; Rand Rare H or alkyl; Rand Rare halogen, H, OH, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, aryloxy, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, carboxy, hydrocarbonyl, alkylcarbonyl, etc.; and Ris halogen atom, H, OH, alkoxy, aryloxy, alkyl or aryl. Each group can be substituted. 

Indazole derivatives

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Ube, Japan

Hidetoshi Sunamoto