Toray Industries, Inc.

Hidetoshi Kozawa

Shigehisa Wada

Hidekazu Nakashima

Kazumi Tanaka

Ichiro Itagaki

Kenji Nishikawa

A dialyzer for blood treatment including a semipermeable membrane which is made of a hydrophobic polymer and a hydrophilic polymer, and has a water permeating performance drying of &#xbd; or higher relative to that before drying. The dialyzer has a vitamin B12 clearance not smaller than 135 ml/mm per 1.6 mor the amount of the hydrophilic polymer eluted from the semipermeable membrane is not higher than 10 ppm. A dialyzer for blood treatment is light-weight, easy to handle, and exhibits a reduced elution of the hydrophilic polymer procedures for producing a dialyzer containing the semipermeable membrane and a process for producing a hollow fiber membrane for use in blood treatment are described.

Dialyzers for blood treatment and processes for production thereof

A dialyzer for blood treatment includes a semipermeable membrane which is made of a hydrophobic polymer and a hydrophilic polymer, and has a water permeating performance drying of &frac12; or higher relative to that before drying. The dialyzer has a vitamin B12 clearance not smaller than 135 ml/min per 1.6 m or the amount of the hydrophilic polymer eluted from the semipermeable membrane is not higher than 10 ppm. A dialyzer for blood treatment is light-weight, easy to handle, and exhibits a reduced elution of the hydrophilic polymer procedures for producing a dialyzer containing the semipermeable membrane and a process for producing a hollow fiber membrane for use in blood treatment as described.

Membrane materials for removing uremic toxins from a hydrophobic polymer such as polysulfone and two polyvinyl pyrrolidones, hydrophilic polymers of different molecular weights, that is 10-50 wt. % of a low molecular weight component (molecular weight<100,000) and 90-50 wt. % of a high molecular weight component (molecular weight&gE;100,000). The membranes are permselective useful in dialysis. The membrane material may have an overall mass transfer coefficient (K ), for a Strokes' radius of at least 30 &angst; (as determined by a diffusion test during dextran), of &gE;0.0025 cm/min and a permeability to albumin of &lE;4%.

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Kyoto, Japan

Hidetoshi Kozawa