Terumo Kabushiki Kaisha

Hideto Ushijima

Hiroaki Takahashi

Shingo Koyama

Hiroyuki Ohnishi

Seiitsu Murota

Ryoichi Nanba

Junji Kimura

Hiroaki Kasukawa

Akira Masuda

Kazuo Kawahara

Hideki Uchiyama

Yoshiyuki Shikata

Syozo Miyaoka

Shozo Miyaoka

Hiroko Sato

This invention provides a liposome having a drug included therein, which has active targeting property and ensured stability in blood and can be used effectively in the diagnosis and/or treatment of diseases, particularly renal diseases, that accompany production of proteoglycan, comprising (1) a basic compound which takes positive charge within a physiological pH range, (2) a lipid derivative of a hydrophilic polymer and (3) a lipid which constitutes the liposome, as its membrane constituting components, wherein their constituting ratios are from 1 to 20 mol % of (1) based on (3) and from 0.2 to 5 mol % of (2) based on the total of (1) and (3).

Liposomes

A novel compound is proposed which is effective in curing various complications as with catarat, retinopathy, neurotic disorder, and renal disorder. The thiazolidine-2,4-dione compound represented by the following general formula I combines an action to inhibit aldose reductase and an action to depress blood sugar and manifests an efficacy in the cure of various complications as with catarat, retinopathy, neurotic disorder, and renal disorder. ##STR1## wherein R.sup.1 is a hydrogen atom or a methyl group.

Thiazolidine-2,4-dione compound and method of treatment of diabetic

Isoprenoid derivatives and pharmaceutical preparations containing the

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Kanagawa, Japan

Hideto Ushijima