Otsuka Pharmaceutical Company, Limited

Taiho Pharmaceutical Company Limited

Hideto Fujiwara

Yasuhiro Menjo

Shigekazu Fujita

Keizo Kan

Hokuto Yamabe

Satoshi Matsuda

Kazuhiro Ohdachi

Taiki Hanari

Tatsuya Urushima

Masatoshi Takuwa

Christopher Norbert Johnson

Steven Howard

Gianni Chessari

Ildiko Maria Buck

Andrew James Woodhead

James Edward Harvey Day

Christopher Charles Frederick Hamlett

Jeffrey David St Denis

Rhian Sara Holvey

Nicholas John Palmer

Steven Douglas Hiscock

John Walter Liebeschuetz

David Geoffrey Twigg

The present invention provides novel benzazepine compounds of Formula (1), or salts thereof, having vasopressin Vand Vantagonisms, and medical uses thereof. In the formula, Ris optionally substituted Calkyl, etc.; L is &#x2014;C(&#x2550;O)&#x2014;NH&#x2014;, etc.; Ring Ais a hydrocarbon ring, etc.; Ring Ais a hydrocarbon ring, etc.; and each of Rings Aand Amay have at least one substituent.

Benzazepine derivatives

The invention provides new pyrazine derivatives of formula (I): or a tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined herein. The invention also provides pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Pharmaceutical compounds

The present invention provides novel benzazepine compounds of Formula (1), or salts thereof, having vasopressin Vand Vantagonisms, and medical uses thereof. In the formula, Ris optionally substituted Calkyl, etc.; L is &#x2014;C(&#x2550;O)&#x2014;NH&#x2014;, etc.; Ring Ais a hydrocarbon ring, etc.; Ring Ais a hydrocarbon ring, etc.; and each of Rings Aand Amay have at least one substituent. 

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Osaka, Japan

Hideto Fujiwara