Kao Corporation

Hidetake Fujinaka

Junji Nakamura

Shigeto Kayane

Hatsumi Souno

Akira Suzuki

Koji Maeda

Yoshinori Murakami

Yasuteru Eguchi

Kazushi Oshino

Hisataka Kobayashi

Mitsuyoshi Kashiwagi

Yoshitaka Yano

Hidenori Yoshida

Ikuhisa Ichimura

Minoru Takizawa

Shinji Kiji

Keiko Kawasaki

Yoshitaka Yanou

Keiko Masuki

A method of quantifying autoinducer-2, including the steps of:

Method of quantifying autoinducer-2

A marker for determining the onset of periodontal disease and a marker far determining the progression stage of periodontal disease, each containing autoinducer-2.

Method of selecting an agent that improves periodontal disease

A marker for determining the onset of periodontal disease and a marker for determining the progression stage of periodontal disease, each containing autoinducer-2.

Method of using autoinducer-2 as a periodontal disease marker

The present invention relates to a method for prevention or treatment of periodontal diseases, containing administering lignans represented by the following formula (1) (wherein Rrepresents a hydrogen atom or a hydroxyl group; R, R, Rand Rare the same or different and each represents a hydrogen atom, a hydroxyl group, a Calkyl group, a hydroxy Calkyl group or a Calkoxy group) or plant extracts containing the lignans.

Method for prevention or treatment of periodontal diseases and composition for an oral cavity

This invention relates to compositions for the oral cavity, each of which comprises (A) a pharmaceutically-active agent, which acts on the periodontium, or a microbicidal agent and (B) an exothermic ingredient or a water-soluble high-molecular substance, and has a water content not higher than 5 wt. %. They permit adsorption of a pharmaceutically-active agent or the like at a high rate on the oral mucosas and are excellent in the effects of preventing and/or treating paradental diseases.

Compositions for oral cavity

The present invention relates to a solid preparation for oral hygiene, which comprises (a) 15 to 90 wt. % of a bubbling component and (b) 0.001 to 10 wt. % of an orally-usable medicinal component at an (a):(b) ratio ranging from 10:1 to 1000:1. Use of the preparation brings about a drastic improvement in the drug efficacy and moreover, breath is freshened by bubbling.

Solid preparation for oral hygiene

Growing community of inventors

Haga-gun, Japan

Hidetake Fujinaka