Nippon Shinyaku Company, Ltd.

Hidetaka Fujihara

Tetsuo Asaki

Katsutoshi Hori

Haruna Naito

The present invention relates to a compound represented by general formula [1] satisfying the following (I) or (II), or a pharmaceutical acceptable salt of the compound. 

Aminopyrazine derivative and medicine

The present invention relates to a compound represented by general formula [1] satisfying the following (I) or (II), or a pharmaceutically acceptable salt of the compound. (I) is CH or N; Ris a halogen atom; and Ris H, a halogen atom, CN, [2], [3], [8], [9], an &#x2014;O-alkyl, an &#x2014;O&#x2014; (saturated ring), etc.[2]: &#x2014;C(R)(R)(R) (Rto Reach are H, an alkyl, etc.)[3]: &#x2014;N(R)(R) (Rand Reach are H, OH, amino, a (hetero)aryl, etc.)[8]: &#x2014;C(&#x2550;O)R(Ris an alkyl, OH, an alkoxy, amino, etc.)[9]: a (substituted)phenyl;(II) X is &#x3e;C&#x2014;C(&#x2550;O)R(Ris a (substituted)amino, an alkoxy, OH, etc.);Ris a halogen atom; and Ris H;andRis H or OH; and Rand Reach are H or an alkyl.

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Kyoto, Japan

Hidetaka Fujihara