Mitsui Toatsu Chemicals, Incorporated

Hideshi Shimizu

Akira Matsubara

Kazutoshi Horikomi

Seitaro Kajiya

Kazuya Sakai

Akira Mizuchi

Norio Ohto

Hideki Tanada

Aminoketone derivative compounds containing a heterocyclic ring bonded to an aminoketone moiety and useful as effective ingredients of centrally acting muscle relaxants and pollakiurea curing agents. (+)3-phenyl-5-[2-(1-pyrrolidinylmethyl)butyryl] isoxazole, which has a more remarkable central muscle relaxant action as compared with its racemic modification, can be effectively separated from the racemic modification using optically active 10-camphorsulfonic acid as the agent for the optical resolution.

Aminoketone derivatives and use thereof

Aminoketone derivative compounds containing a heterocyclic ring bonded to an aminoketone moiety and useful as effective ingredients of centrally acting muscle relaxants and pollakiurea curing agents. (+)3-phenyl-5-[2-(1-pyrrolidinylmethyl)butyryl]isoxazole, which has a more remarkable central muscle relaxant action as compared with its racemic modification, can be effectively separated from the racemic modification using optically active 10-camphorsulfonic acid as the agent for the optical resolution.

Aminoketone derivative and use thereof

Aminoketone derivatives of 1,2-oxazole and use thereof

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Kanagawa, Japan

Hideshi Shimizu