Sankyo Company, Limited

Sankyo Agro Company, Limited

Hideshi Okui

Shigeru Mio

Yoshihisa Tsukamoto

An N-heteroaryl-4-(haloalkyl)nicotinamide derivative represented by formula (I):[wherein R represents a C&#x2013;Chaloalkyl group; Rrepresents a hydrogen atom, a C&#x2013;Calkyl group which may be substituted a C&#x2013;Calkenyl group or an acyl group; X represents a group represented by formula C&#x2014;R, or a nitrogen atom; Rand Reach independently represent a hydrogen atom, a halogen atom, a C&#x2013;Calkyl group which may be substituted, a C&#x2013;Ccycloalkyl group, a C&#x2013;Calkenyl group, a C&#x2013;Ccycloalkenyl group, a formyl group, a group represented by formula CH&#x2550;NOR, a cyano group, a phenyl group which may be substituted, a heterocyclic group which may be substituted, a C&#x2013;Calkoxy group which may be substituted, a C&#x2013;Calkylthio group or a phenoxy group]; or a salt thereof, a pesticide containing it as an active component, a method for producing it and intermediates thereof.

[object Object]

A process for the preparation of a cinnamic acid ester comprises condensing a benzaldehyde with an acetic acid ester in the presence of a base. The reaction mixture is then treated, without adding an additional solvent or after adding an additional solvent, with an acid to convert a 3-alkoxy-3-phenylpropionic acid ester in the reaction mixture into a corresponding cinnamic acid ester. This procedure allows cinnamic acid ester derivatives of high-purity to be obtained in good yield.

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Shiga, Japan

Hideshi Okui