Otsuka Pharmaceutical Factory, Inc.

Takeda Chemical Industries, Inc.

Hideshi Okamoto

Keiichi Kawakami

Yuki Manabe

Fujio Inoue

Isamu Tateishi

Masamitsu Izumi

Koichi Takeda

Katsushi Watanabe

Katsuyoshi Nagao

Hidekatsu Shoji

Tadaaki Inoue

Yoshiki Maesaki

Tetsuya Hatono

Takayuki Hagiwara

Hirohisa Taniguchi

An object of the present invention is to provide a plastic ampule capable of suppressing volatilization and scattering of a drug solution and elution of plastic compounding ingredients into the drug solution, as well as suppressing whisker formation and deformation and damage of an opening when the plastic ampule is opened. A plastic ampuleaccording to the present invention includes a drug solution storage partfor storing a drug solution, a drug solution discharge tubein communication with the drug solution storage partand extending toward one side, and a top partclosing an end at the one side of the drug solution discharge tube, and the drug solution discharge tubeincludes a fragile partformed to have a thin thickness along a circumferential direction. The drug solution storage part, the drug solution discharge tube, and the top partare formed of a multilayer plastic material that includes an intermediate layer containing a cyclic olefin-based (co)polymer with a glass transition temperature of 60 to 80&#xb0; C., an inner layer laminated to an inner side of the intermediate layer, an outer layer laminated to an outer side of the intermediate layer, and adhesive layers respectively disposed between the intermediate layer and the inner layer and between the outer layer and the intermediate layer.

Plastic ampule and colored plastic container

A drug solution filling plastic ampoule having gas, steam and light ray barrier properties, a drug permeation preventing capability and an absorption/adsorption preventing capability, and a production method for the plastic ampoule. The drug solution filling plastic ampoule includes a container body, a fusion-bonded portion which seals a mouth of the container body, and a wrench-off holder tab connected to the fusion-bonded portion. The ampoule is formed from a parison including two or more layers, at least one of which is a functional layer having at least one characteristic property selected from the group consisting of a gas permeation preventing capability, a steam permeation preventing capability, a light ray permeation preventing capability, a drug permeation preventing capability and a drug absorption/adsorption preventing capability.

Drug solution filling plastic ampoule and process for producing the same

Disclosed is a multi-layer film comprising: a surface layer having a thickness of 10 to 50 &#x222b;&#xca;m made of an ethylene-&#x222b;-olefin copolymer having a density of 0.935 to 0.950 g/cm3, a flexible layer having a thickness of 100 to 200 &#x222b;&#xca;m made of an ethylene-&#x222b;-olefin copolymer having a density of 0.860 to 0.930 g/cm3, a barrier layer having a thickness of 10 to 80 &#x222b;&#xca;m made of a mixed resin containing 60 to 95% by weight of a cyclic olefin polymer and 5 to 40% by weight of an ethylene-&#x222b;-olefin copolymer having a density of 0.900 to 0.965 g/cm3, and a seal layer having a thickness of 5 to 80 &#x222b;&#xca;m made of an ethylene-&#x222b;-olefin copolymer having a density of 0.910 to 0.950 g/cm3. This multi-layer film is suited for use as a material for production of a medicine containerbecause it suppresses adsorption of a medicine by the barrier layer and is also superior in strength and flexibility.

Multi-layer film and medicine container using the same

Multilayer film and container

Medicine container

Growing community of inventors

Tokushima, Japan

Hideshi Okamoto