The Rockefeller University

Hidesaburo Hanafusa

Kathy S Fang

John Kuriyan

David Cowburn

Irwin H Gelman

Stephan M Feller

Stephen S Morse

Beatrice S Knudsen

Jie Zheng

Xiaodong Wu

The present invention relates to regulation and control of cellular processes by SH3-domain binding proteins and peptides. In particular, the invention provides a consensus sequence of a peptide that shows high specificity and affinity for the first SH3 domain of cellular Crk. In specific examples, a number of peptides that contain the consensus are shown to bind c-Crk specifically. The molecular basis for this specificity is examined by crystallography.

Peptides specific for the first Crk-SH3 domain

The present invention relates to regulation and control of cellular processes by transmembrane protein tyrosine phosphatases, and to ligands that agonize or antagonize tyrosine phosphorylation mediated by such tyrosine phosphatases. This invention further relates to diagnosis and therapy based on the activity of such ligands. In particular, the invention provides a novel transmembrane protein tyrosine phosphatase-.lambda. (PTP.lambda.), nucleic acids encoding the same, antibodies to the PTP.lambda., and methods for identifying ligands to the PTP.lambda. of the invention. A specific Example describes the isolation and characterization of the first chicken transmembrane PTP, called ChPTP.lambda.. It has a unique extracellular domain containing a Ser/Thr/Pro-rich region, spectrin-like repeats, a fibronectin III domain, and an alternatively spliced N-terminus. The expression of ChPTP.lambda. in various tissues and cells was also examined. ChPTP.lambda. was shown to have a tyrosine-specific phosphatase activity, and the basic characteristics of this enzyme were studied.

Transmembrane tyrosine phosphatase and methods of use thereof

Transmembrane tyrosine phosphatase, nucleic acids encoding the same, and

Nucleic acid oligonucleotide probes or primers that hybridize specifically and exclusively to two regions of the pol gene, identified as LV I and LV II, conserved among a wide range of lentiviruses, wherein the preferred amino acid sequences of the conserved regions are:

Lentivirus-specific nucleotide probes and methods of use

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New York, NY, United States of America

Hidesaburo Hanafusa