Sumitomo Electric Industries, Limited

Other

Kanebo, Limited

Smart Targeting Limited

Ko Okumura

Hideo Yagita

Motomi Nakata

Nobuhiko Kayagaki

Sachiko Miyake

Hiroshi Eto

Hiroyasu Nakano

Tadashi Nishida

Makoto Sunamura

Ken-ichiro Seino

Yukihito Hasunuma

The present invention provides a binding protein capable of binding to delta-like ligand 4 (DLL4) as well as methods and uses thereof in therapy, diagnosis or imaging. Also provided are fusion proteins and protein conjugates, nucleic acid molecules encoding the binding proteins and methods of preparing binding proteins capable of binding to DLL4.

Neutralizing monoclonal antibody against human DLL4

The invention provides monoclonal antibodies, which specifically react with a Fas ligand, or active fragments thereof, a production process of the monoclonal antibodies, which specifically react with a Fas ligand, hybridomas separately producing a monoclonal antibody, which specifically reacts with a Fas ligand present on a cell surface, a method of detecting a Fas ligand in a solution, and a kit for use in detecting a Fas ligand, comprising plurality of monoclonal antibodies against Fas ligand in combination.

Monoclonal antibody reacting specifically reacting with Fas ligand and production process thereof

This invention relates to a TRAF family molecule, a polynucleotide encoding the molecules, an antibody against the molecules, and an antisense polynucleotide of the molecule. Employing an oligo-DNA primer capable of amplifying the most highly conserved region of a known TRAF family molecule, PCR was performed with the aid of cDNA derived from various cell strains and tissues as a template. Thus, the base sequence of the gene of an unknown TRAF family molecule and the amino acid sequence of the TRAF family molecule encoded by the gene were elucidated. An antibody against the molecule was also prepared. By utilizing the TRAF family molecules, genes thereof, and antibodies against the molecules, there are provided methods for elucidating the functions of the proteins and methods for elucidating the signal transduction system of the TNF-R family involving the molecules, as well as probes for research and diagosis, which suggest applications in therapeutic agents.

TRAF family molecules, polynucleotides encoding them, and antibodies against them

Antibodies to Fas-L for treatment of hepatitis

Drug for the treatment of rheumatoid arthritis

A monoclonal antibody specifically reactive to hamster immunoglobulins, a hybridoma producing said monoclonal antibody, and an immunoassay utilizing said monoclonal antibody are provided. The monoclonal antibody is useful in an immunoassay as a secondary antibody to a hamster-derived primary antibody or antiserum raised against various antigens.

Antibody reactive to hamster immunoglobulins and assay using same

Growing community of inventors

Tokyo, Japan

Hideo Yagita