Hamamatsu-Photonics K.k.

Riken Corporation

Gifu University

Nard Institute, Ltd.

Hideo Tsukada

Shingo Nishiyama

Norihiro Harada

Kengo Sato

Masaaki Suzuki

Hisashi Doi

Tatsuhiro Kobashi

Hiroyuki Ohba

Hidekazu Nakao

Takeru Kitashoji

Masakatsu Kanazawa

Yumi Nakamasu

The present invention provides a diagnostic agent for a therapeutic effect on cancer, containing a compound represented by formula (1-0). (In formula (1-0), R represents &#x2014;O(CH)&#x2014;, &#x2014;O(CH)OCH&#x2014;, &#x2014;CHO(CH)&#x2014;, or &#x2014;CHO(CH)OCH&#x2014;, n represents an integer of 1 to 5, and Qrepresents F or &#x2014;OCH.)

Diagnostic agent for therapeutic effect on cancer

The present invention provides a compound represented by formula (I), wherein in formula (I), Rrepresents CH, F, (CH)&#x2014;F, NH&#x2014;(CH)&#x2014;F, O&#x2014;(CH)&#x2014;F or S&#x2014;(CH)&#x2014;F, and n represents an integer of 1 to 3. 

Compound suitable for detection of vesicular acetylcholine transporter

Provided is a compound represented by formula (1-0): wherein in formula (1-0), R represents &#x2014;O(CH)&#x2014;, &#x2014;O(CH)OCH&#x2014;, &#x2014;CHO(CH)&#x2014; or &#x2014;CHO(CH)OCH&#x2014;; n represents an integer from 1 to 5; and Qrepresents F or &#x2014;OCH.

Compound suitable for detection of mitochondrial complex-1

It is intended to provide a radioactive tyrosine derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof: wherein Rrepresents a group selected from the group consisting of &#x2014;CH, &#x2014;CHCH, &#x2014;CHF, and &#x2014;CHCHCHF.

Radioactive tyrosine derivative, method for producing same, labeling agent for positron imaging and medical agent for assessing grade of malignancy of tumor respectively composed of radioactive tyrosine derivative, and method for detecting tumor

A method of rapid methylation of an aromatic compound or an alkenyl compound, which is capable of obtaining an aromatic compound or an alkenyl compound labeled with a methyl group or a fluoromethyl group under a mild condition rapidly in high yield using an organic boron compound whose toxicity is not so high as a substrate. A kit for preparing a PET tracer and a method of producing a PET tracer can be practiced using the rapid methylation method. In an aprotic polar solvent, methyl iodide or X&#x2014;CH2F (wherein X is a functional group which can be easily released as an anion), and an organic boron compound in which an aromatic ring or an alkenyl group is attached to boron are subjected to cross-coupling in the presence of a palladium(0) complex, a phosphine ligand, and a base.

Method of rapid methylation, kit for preparing PET tracer and method of producing PET tracer

In a PET apparatusin a calculation processing unitfor each frame, radiation data for a region of interest K of a measurement-subjected part H is extracted, and then the optimum administration rate of a labeled substance T is calculated based on the radiation data such that the radiation concentration for the region of interest K will be steady regardless of the physiological state (blood flow rate etc.) of the subject S. In an administration rate control unitfeedback control of the administration rate of the labeled substance into the subject S is carried out based on the calculated optimum administration condition. As a result, the change in the amount accumulated of the labeled substance T in the region of interest K between before and after administration of a drug being tested Y can be obtained easily and precisely in real time as the amount of change in the radiation concentration, and it becomes possible to grasp the measurement results rapidly and easily.

Growing community of inventors

Hamamatsu, Japan

Hideo Tsukada