Riken Corporation

Rikagaku Kenkyusho

The Institute of Physical and Chemical Research

Other

Nec Tokin Corporation

Doryokuro Kakunenryo Kaihatsu Jigyodan

Waseda University

Machida Endoscope Co., Ltd.

Megaopto Co., Ltd.

Hideo Tashiro

Satoshi Wada

Akitake Makinouchi

Jie Zhang

Kiwamu Kase

Kazuyuki Akagawa

Tokuji Kitsunai

Yasumitsu Kondoh

Hitoshi Ohmori

Masahiro Anzai

Tomoko Tashiro

Yoshihide Hayashizaki

Shlomo Ruschin

Takahiko Nojima

Shigeori Takenaka

Yuichi Komachi

Ryutaro Himeno

Kazuko Matsumoto

Hidetoshi Sato

Kouichi Toyoda

Katsuo Aizawa

Akihiro Iimura

Yoshiharu Urata

Takayo Ogawa

Koji Sugioka

Hiroshi Machida

Mikio Higuchi

Kohei Kodaira

Tomohiro Shonai

Jihong Geng

Touji Nakazawa

Koichi Toyoda

Mitsutoshi Suzuki

Katsumi Midorikawa

Masataka Morita

Satoru Hatakeyama

The substrate for biomolecule microarray has one or more spots for immobilizing a biomolecule. The spot for immobilizing a biomolecule protrudes from the surface of the substrate and has a flat surface for spotting on the top thereof, at least the surface of the substrate around the protruding spot part, the lateral surface of the protruding spot part and the flat surface for spotting are comprised of an electrically conductive substance. Alternatively, the spot for immobilizing a biomolecule protrudes from the surface of the substrate and has a flat surface for spotting on the top thereof, the protruding spot parts adjacent each other border through the lateral surface of the protruding spot part, and at least the lateral surface of the protruding spot part and the flat surface for spotting are comprised of an electrically conductive substance. The biomolecule microarray comprises the above substrate and a biomolecule and the biomolecule is immobilized on at least the flat surface for spotting on the substrate. The device of promoting interaction between biomolecules comprises a biomolecule microarray having one or more biomolecule-immobilized spots on a substrate, an electrode provided so as to face the surface having the biomolecule-immobilized spots of the microarray, and a power source for applying an electric field between the microarray and the electrode. The method of promoting interaction between biomolecules employing the above device. The method of detecting interaction between biomolecules. Provided are a substrate having biomolecule immobilization regions of prescribed shape on a biomolecule microarray, and means by which the interaction of biomolecules is rapidly conducted, the interaction of trace quantities of sample is promoted, and the interaction is detected and analyzed rapidly and with high sensitivity.

Substrate for biomolecule microarray, biomolecule microarray, device and method of promoting interaction, and method of detecting interaction

V-CAD data is prepared by dividing external dataconsisting of boundary data of an object into rectangular parallelepiped cellshaving boundary planes orthogonal to each other in accordance with octree division and separating the respective divided cells into internal cellspositioned on the inner side of the object and boundary cellsincluding a boundary face, and a modeling unit quantity of a prototyping materialis changed in accordance with sizes of the internal celland the boundary cellof a modeling portion. The prototyping materialis a resin, lumber powder, a low-fusing-point metal, metal powder, ceramics powder or a mixture of a binder and one of these materials, and its modeling unit quantity is set in such a manner that the modeling unit quantity is smaller than a capacity of a corresponding cell and does not protrude from the boundary plane of the cell. As a result, by using the V-CAD data, a program for rapid prototyping can be simplified, and a model production time can be greatly reduced.

Rapid prototyping method and apparatus using V-CAD data

A method of evaluating a non-linear optical crystal used for non-linear wavelength conversion of laser beam which enables the non-linear optical crystal to be evaluated before the crystal is actually used as a wavelength conversion element in order for the crystal to be constantly used for an extended time with a high conversion efficiency retained and without lowering in output when non-linear optical crystals for various non-linear wavelength conversions such as a CLBO crystal are used to convert laser beams, wherein the non-linear optical crystal is moved to changed a laser beam incident position to detect the output of a laser beam emitted from the non-linear optical crystal for each changing position.

Method of evaluating non-linear optical crystal and device therefor and wavelength conversion method and device therefor

A Raman probe for measuring Raman spectrum includes an exciting-end light guiding path for guiding excitation light from a light source to a sample; a receiving light-guide path for guiding a light signal from said sample to a detector; a band-pass filter for passing said excitation light and blocking Raman-scattered light produced from said exciting-end light guiding path; a pipe for securing said band-pass filter inside said pipe, said pipe being mounted on a light-outgoing end of said exciting-end light guiding path; and an edge filter mounted on a light-incident end of said receiving light-guide path, said edge filter passing Raman-scattered light from said sample while blocking the excitation light. The edge filter is a short-wavelength transmitting filter that permits passage of wavelengths shorter than the excitation wavelength.

Raman probe and Raman spectrum measuring apparatus utilizing the same

(A) V-CAD data of an object () is prepared. (B) A processed surface shape after NC processing is predicted by simulation using the V-CAD data. (C) The object is subjected to NC processing by a predetermined NC program, and a processed surface shape after NC processing is measured, and (D) processing correction data is obtained from a difference between the processed surface shapes acquired by simulation and measurement, and the NC program is corrected based on the processing correction data. As a result, the ultra-precise processing is enabled even if a workpiece or a tool has low rigidity and an inconstant quantity of deformation.

Ultra-precise processing method and apparatus for inhomogeneous material

There is prepared V-CAD data obtained by dividing external dataconsisting of boundary data of an object into rectangular parallelepiped cellshaving boundary planes orthogonal to each other in accordance with octree division and separating the respective divided cells into internal cellspositioned on the inner side of the object and boundary cellsincluding a boundary face, and mold data and mold processing data used to manufacture the object are generated from data of a reference plane which at least partially comes into contact with the objectand the V-CAD data. Further, in the mold processing data, a plurality of the processing toolsare selected in descending order of a size in accordance with sizes of the internal cellsof a processing portion, and the processing toolis moved in a plane of the mold and in the thickness direction, thereby processing the mold. As a result, by using the V-CAD data, the NC processing program for mold processing can be simplified, and the mold processing time can be greatly reduced.

Die machining method and device by V-CAD data

A method of storing substantial data integrating shape and physical properties comprising (A) inputting external dataconsisting of boundary data of an object, (B) dividing, by modified Octree division, the external data into cubical cellswhich boundary surfaces are orthogonal to each other, and (C) storing the values of various physical properties for each of the cells. Furthermore, in step (B), each of the divided cellsis classified to non-boundary cellslocated in the interior of the object or in a region outside of the object, and boundary cellsincluding boundary surfaces. Thereby, substantial data integrating shape and physical properties can be stored in small storage capacity, thus enabling the integration of CAD and simulation.

Storage method of substantial data integrating shape and physical properties

To provide a laser oscillation method and a laser device, which use a laser medium such as an Nd:GdVOcrystal to which neodymium is doped in high concentration exceeding 1% in atomicity ratio, the laser medium comprised of the gadolinium-vanadate crystal to which neodymium as laser active ion is doped by a floating zone method such that concentration becomes exceeding 1% in atomicity ratio.

Laser oscillation method and laser device

This invention provides a kit used for fabricating an integrated biomolecule sensor. The kit includes an optical fiber bundle unit, which holds the proximal ends of the plurality of optical fibers together with the end-face arranged substantially in the same plane and oriented substantially in the same direction, a plate with wells for holding solutions containing probe polymers with different base sequences, and an auxiliary plate having holes, which corresponds to the wells of the plate respectively. According to this invention, researchers and other people can easily fabricate the integrated biomolecule under individual requirements without need of expensive equipment.

Kit used for fabricating an integrated biomolecule sensor

An integrated biomolecule sensor comprising a plurality of optical fibers whose proximal ends are held together with the end-faces arranged substantially in the same plane and oriented substantially in the same direction and which have probe polymers with different base sequences bound to the core end-face at their distal ends. The method and apparatus for fabricating the integrated biomolecule sensor, and the method and apparatus for detecting biomolecules using the integrated biomolecule sensor are also disclosed. Researchers can make their own sensors best suited for individual requirements, and detect the presence of target biomolecules quickly, without need of expensive equipment.

Integrated biomolecule sensor, method and apparatus for fabricating the sensor, and method and apparatus for detecting biomolecules using the sensor

For the sake of no needing to provide a mechanically actuating section such as a rotating mechanism thereby to be capable of realizing stable ultrashort pulse laser oscillation, an ultrashort pulse laser oscillator comprises a laser resonator composed of a mirror on outgoing side, and a total reflection mirror; a continuous wave oscillation laser for inputting excitation laser beam; a tunable laser medium capable of laser oscillation; a photoacoustic optical crystal having birefringent property as a crystal for selecting wavelength to which is input outgoing light from the tunable laser medium; a piezoelectric element inputting an acoustic wave having a frequency in response to a distortion upon application of voltage; a power source for applying the voltage; and a control means for controlling a frequency of voltage to be applied to the piezoelectric element by the power source wherein a frequency of voltage to be applied to the piezoelectric element by the power source is controlled by means of the control means, whereby the voltage having a frequency conforming to a distance defined between the mirror on outgoing side and the total reflection mirror is applied to the piezoelectric element by means of the power source, besides laser beam output from the mirror on outgoing side is utilized as outgoing laser beam from the laser resonator.

ultrashort pulse laser oscillator

(A) The surface shape of an object ( ) is measured by varying the position and/or direction of measurement, and a plurality of sets of partially measured data ( ) including the common parts ( ) are acquired, (B) for all the partially measured data ( ), the overlapped ranges ( ) of the adjacent common parts ( ) are determined within the measurement error ranges ( ), (C) when there are no superposition ranges ( ), it is decided that a combination is not possible, and (D) when there are overlapped ranges ( ), the common parts of each set of partially measured data are combined within the ranges. Thus, combined data can be created at a high accuracy from a plurality of sets of partially measured data based on a small number of repeated calculations.

Method for combining partially measured data

A present micro array manufacturing apparatus includes a substrate placement portion on which a plurality of substrates can be arranged, a tighter plate for storing a solution including a living body sample, a solution storing member for taking in the solution from the tighter plate and storing the solution therein, and a needle which can be inserted into the solution storing member to allow the solution stored in the solution storing member to adhere onto each of the substrates by a given quantity, wherein the solution storing member and needle are moved in directions where they approach and part away from the substrates to thereby form spots on the substrates. And, the individual operations of the solution storing member and needle are carried out by single drive means

Micro array manufacturing apparatus

A laser device which has an excellent characteristic originally exerted by an yttrium-aluminum-garnet crystal doped with neodymium and is entirely reduced in size by using an entirely downsized laser medium is provided. The laser device is constituted such that a laser medium is disposed in a resonator, excited light is incident upon the laser medium so as to cause laser oscillation in the resonator, and laser light is emitted from the resonator. An yttrium-aluminum-garnet single crystal is used as the laser medium, in which neodymium is added at a concentration exceeding an atomicity ratio of 1.3%.

Laser device

Detecting reagent for double-stranded nucleic acid and double-stranded nucleic acid detecting method

Growing community of inventors

Wako, Japan

Hideo Tashiro