Mitsubishi Mining and Cement Co. Ltd.

Other

Tohkai Ceramic Material Co., Ltd.

Hideo Tagai

Shigeo Niwa

Mikiya Ono

Kazuhiko Sawai

Hiroyasu Takeuchi

Masahiro Kobayashi

Torao Ohtsuka

Makoto Fukaya

Yoshiaki Fukuda

Tomokazu Hattori

Takayuri Kato

Shinpei Hashimoto

Shinobu Takahashi

Hajime Ohta

Yoshikatsu Kuroki

A hydroxylapatite base porous beads filler for use in cure of an injured or diseased part of bone of an organism. The porous filler is comprised of fired hydroxylapatite base beads each of which is formed with many pores. Each pore of the bead has a diameter of 1 to 100 .mu.m and a length larger than the diameter. Each bead has a porosity of 10 to 50% and a diameter of 0.02 to 20 mm. The pores of the bead may be filled with a solution containing a pharmaceutical in order to promote the cure of the injured or diseased part.

Hydroxylapatite base porous beads filler for organism and method of

A biomedical material in use for curing the bone defect or the like in human being or an animal. The biomedical material is comprised of a flexible fiber-meshed micro-tube which has an outer diameter ranging from 50 .mu.m to 10 mm and is formed of a net or a cloth woven from fibers. The fibers are biodegradable and capable of maintaining their shape within a time period ranging from 1 week to 30 weeks in the body. Additionally, hydroxylapatite beads and/or flakes are filled in the fiber-meshed micro-tube. The biomedical material is located in the bone defect or the like under an operation, in which blood can effectively circulate through the mesh of the micro-tube and through the spaces among the hydroxylapatite beads and/or flakes, thereby promoting the cure of the bone defect or the like.

Biomedical material including tube-like biodegradeable nety works filled

A method of producing a hydroxylapatite base porous beads filler for an organism, including mixing hydroxylapatite powder having particle sizes not larger than 125 .mu.m, in an amount ranging from 40 to 90% by weight, synthetic resin powder having particle sizes not larger than 74 .mu.m, in an amount ranging from 5 to 55% by weight, and resinous binder in an amount ranging from 0.5 to 5% by weight to obtain a mixture, granulating the mixture to form beads each having a diameter ranging from 0.03 to 25 mm, firing the beads at a temperature ranging from 900.degree. C. to 1180.degree. C. to form hydroxylapatite base porous beads, dipping the porous beads in a colloidal solution, removing air from the porous beads under vacuum, and filling the colloidal solution into the pores in the porous beads under pressure.

Method of producing hydroxylapatite base porous beads filler for an

An implant material for replacing hard tissue of a living body is provided. The implant material comprises 10 to 90 wt % of a fiber glass and 90 to 10 wt % of an organic high polymer material. The fiber glass is mainly composed of calcium phosphate. The organic high polymer material does not inhibit affinity with the living body. On the surface of the implant material, a portion of the fiber glass is exposed.

Implant material for replacing hard tissue of living body

A method of manufacturing calcium phosphate using phosphorus in plants. The method comprising the steps of firstly slurrying raw material containing phosphorus, including plants particularly such as soybean, corn, oil meal of the rice bran and the like; adding one or more selected among oxide, hydroxide and carbonate of calcium to the slurry and mixing them; controlling Mg component derived from the raw material so that the Mg/Ca mole ratio is in the range of 0.25 or less; dehydrating and drying them; controlling pH of the slurry and 7.5 or higher and slowly heating them within the temperature range from 150.degree. C. to 650.degree. C. in the oxidation atmosphere to dissipate and remove carbon; and finally raising the temperature to burn them within the temperature range from 700.degree. C. to 1550.degree. C. in the oxidation atmosphere.

Method of manufacturing calcium phosphate using phosphorus in plants

A fiber glass is provided for filling in a defect or hollow portion of bone. The fiber glass comprises calcium phosphate as a main ingredient and has a negative zeta potential. The calcium phosphate has a molar ratio of Ca/P of not less than 0.2 and less than 0.6 and the total content of CaO plus P.sub.2 O.sub.5 in the fiber glass is less than 80 wt %. The fiber glass is of long filament form or staple fiber form. The fiber glass of long filament form may be woven to form a woven filler.

Fiber glass mainly composed of calcium phosphate

A fiber glass is provided for filling in a defect or hollow portion of bone. The fiber glass comprises calcium phosphate as a main ingredient and has a negative zeta potential. The calcium phosphate has a molar ratio of Ca/P of not less than 0.2 and less than 0.6 and the total content of CaO plus P.sub.2 O.sub.5 less than 80 wt %. The fiber glass is of long filament form or staple fiber form. The fiber glass of long filament form may be woven to form a woven filler.

A filler for filling in defects or hollow portions of bones to coalesce with the bone tissues is provided which comprises powders of a calcium phosphate compound having the apatite crystalline structure of each crystallite size of 400 .ANG. or larger and of each crystal grain size of 3 .mu.m or smaller, said calcium phosphate compound being represented by the following general formula of Ca.sub.m (PO.sub.4).sub.n OH (1.33.ltoreq.m/n.ltoreq.1.95), and said powders being fluidized or plasticized.

Filler for filling in defects or hollow portions of bones

A filler for filling in defects or hollow portions of bones to coalesce with the bone tissues is provided which comprises powders of a calcium phosphate compound having the apatite crystalline structure of each crystal grain size of from 50 .orgate. to 10 microns and represented by the following general formula of Ca.sub.m (PO.sub.4).sub.n OH (1.33.ltoreq.m/n.ltoreq.1.95); and said powders being adapted for filling in a fluidized or plasticized state. A method of treating a bone with the filler is also provided wherein at least a portion of said filler is filled in to reach the bone-marrow cavity of said bone.

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Tokyo, Japan

Hideo Tagai