Kyorin Pharmaceutical Co., Ltd.

Kyorin Seiyaki Kabushiki Kaisha

Hideo Okubo

Tsutomu Irikura

Seigo Suzue

Kyuya Okamura

Hiroyuki Miyachi

Mitsuru Segawa

Shigeru Yamanaka

Hidemichi Mizuguchi

Emiko Tagami

Katsuya Awano

Arylglycinamide derivatives represented by a general formula (1) ##STR1## (wherein Ar denotes a phenyl group which may have 1 to 3 substituents or naphthyl group which may have 1 to 3 substituents, R.sub.1 and R.sub.4 denote identically or differently hydrogen atoms or lower alkyl groups with 1 to 3 carbon atoms, R.sub.2 denotes a lower alkyl group with 1 to 6 carbon atoms, cycloalkyl group with 3 to 6 carbon atoms, lower alkyl group with 1 to 4 carbon atoms which may have a phenyl group which may have 1 to 3 substituents, norbornyl group, adamantyl group or phenyl group which may have 1 to 3 substituents, R.sub.3 denotes a hydrogen atom or lower alkyl group with 1 to 6 carbon atoms or it may form a ring constituting alkylene together with R.sub.2, R.sub.5 denotes a lower alkyl group with 1 to 6 carbon atoms or cycloalkyl group with 5 or 6 carbon atoms, R.sub.6 denotes a hydrogen atom or lower alkyl group with 1 to 6 carbon atoms or it may form a ring constituting alkylene together with R.sub.5, and m denotes 2 or 3), and their salts, which function as effective therapeutic drugs for the dysurias such as urinary incontinence and pollakiuria, and the preparative processes therefor are presented.

Arylglycinamide derivatives and preparative processes therefor

This invention relates to sulfamoylbenzoic acid derivatives which possess diuretic and uricosuric activities, and which are of the formula (I) ##STR1## wherein R.sub.1 is a chlorine atom or phenoxy group, R.sub.2 is a hydrogen atom, halogen atom, lower alkyl group, lower alkoxy group or methylenedioxy group.

Novel sulfamoylbenzoic acid derivatives, process for their preparation

This invention relates to new and useful pyrazolopyridine and tetrahydro pyrazolopyridine derivatives which possess inhibitory activities on platelet aggregation. More particularly, it relates to method for their production as well as therapeutic compositions containing these compounds as used in cerebral and peripheral vascular insufficiency and its complications.

Pyrazolopyridines and tetrahydro pyrazolopyridines

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Nogi, Japan

Hideo Okubo