Suntory Holdings Limited

Seed Research Institute Co., Ltd.

Op Bio Factory Co., Ltd.

Hideo Naoki

Morita Iwami

Yasufumi Ohfune

Terumi Nakajima

Sachi Kato

Tetsuro Shinada

Yoshimi Matsumoto

Kazuya Murata

Provided are a compound having a novel mother nucleus, which can be a promising drug discovery seed compound, use thereof as an antifungal agent, and a production method thereof and the like. A compound represented by the following formula: or a pharmaceutically acceptable salt thereof, and an antifungal agent containing same, and the like.

Microbial product having antifungal activity

A method for effectively causing charge-remote fragmentation (CRF) when the structural analysis of an nitrogen-containing organic compound is performed using a high-energy collisional-induced dissociation-mass/mass spectrum (CID-MS/MS spectrum), a reagent to be used in such a method, and a method for analyzing an organic compound by the induction of CRF are provided. The method for the induction of charge-remote fragmentation (CRF) using a high-energy collisional-induced dissociation-mass/mass spectrum (CID-MS/MS spectrum) has the step of: introducing a squaric acid residue into an end of a nitrogen-containing organic compound. The squaric acid residue is represented by a chemical formula (I):  The reagent is provided for introducing such a squaric acid residue. Furthermore, the method is provided for analyzing such an organic compound by the induction of CRF.

Mass spectrometric method for structural analysis of chain nitrogen-containing compounds using sqauric acid

Growing community of inventors

Sakai, Japan

Hideo Naoki