Otsuka Pharmaceutical Company, Limited

Hideo Mori

Kazuyuki Nakagawa

Nanami Murakami

Shiro Yoshizaki

Michiaki Tominaga

Kaoru Tanimura

Novel compounds represented by the formula ##STR1## wherein R.sup.1, R.sup.2, R' and R' are defined as hereinafter, having a blocking activity on .beta.-adrenergic nerves, novel intermediates useful for synthesis thereof and processes for preparing the same are disclosed. When substitution is at the 5-position and R.sup.1 and R.sup.2 are hydrogen, R' and R' are not simultaneously hydrogen and a 1 to 4 carbon atom alkyl group in the claimed compound.

3,4-Dihydrocarbostyril derivatives

Novel compounds represented by the formula ##STR1## wherein R.sup.1, R.sup.2, and R' and R' are defined as hereinafter, having a blocking activity on .beta.-adrenergic nerves, novel intermediates useful for synthesis thereof and processes for preparing the same are disclosed. When substitution is at the 5-position and R.sup.1 and R.sup.2 are hydrogen, R' and R' are not simultaneously hydrogen and a 1 to 4 carbon atom alkyl group in the claimed compound.

3,4-Dihydrocarbostyril derivatives and process for producing the same

A glycerol derivative represented by the formula (I) ##STR1## wherein A is hereinafter defined, including the optically active isomers per se and mixtures of the optically active isomers, which are useful as a central nervous system depressant, an intermediate for the preparation of .beta.-adrenergic blocking agents, an inhibitor of blood platelet aggregation or a choleretic agent, and a process for preparing the above glycerol derivative.

Glycerol derivatives of quinoline carbostyryl and isocarbo styryl

2-Hydroxy-3-alkylaminopropoxycarbostyrils represented by the formula (I) ##SPC1## wherein R represents a straight or branched chain alkyl group having 1 to 4 carbon atoms useful as .beta.-adrenergic blocking agents and a process for preparing the same are disclosed.

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Tokushima, Japan

Hideo Mori