Daiichi Pharmaceutical Co., Ltd.

Honda Motor Co., Ltd.

Nippon Soda Co., Ltd.

Hideo Kubo

Yoshio Yazaki

Satoru Kato

Tadahiro Shinohara

Tomoichiro Asano

Akira Kanda

Tetsuya Mimura

Upper and lower support members, supporting a valve, are lowered toward a valve guide with at least the lower support member vibrated by a vibrating device. When a lower-end chamfered surface of the valve has failed to be brought into contact with the opening edge of the guide through the lowering, not only the upper support member is caused to gradually move away from an umbrella section of the valve but also the position of supporting, by the lower support member, of a shaft section of the valve is displaced downward after the lower end of the shaft section of the valve contacts the upper end surface of the guide, so that vibrating movement of the lower end of the shaft section is reduced to allow the chamfered surface to contact the opening edge. Then, the valve is inserted into the guide by a pressing member.

Method and apparatus for inserting a valve into a valve guide

The present invention provides methods of inhibiting or sequestering 14-3-3 protein from binding to the insulin receptor substrate &minus;1 or &minus;2 by administering a substance which inhibits the interaction of these two proteins.

Remedies for diseases caused by insulin resistance

A compound of formula (I) possesses excellent potassium channel opening activity and is effective on various diseases arising from contractions of blood vessels, bronchial smooth muscles, etc., for example, ischemic heart diseases exemplified by angina pectoris, asthma, pollakisuria, sequela of subarachnoid hemorrhage, peripheral arterioinfarct, and so on. The compound has potent and long-lasting antihypertensive activity, with the onset of the action being slow, excellent activity in increasing renal blood flow, and high safety, and is therefore particularly useful as an antihypertensive. ##STR1## The substituents are as defined in the specification.

Diazabicycloalkene derivatives

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Tokyo, Japan

Hideo Kubo