Kaneka Corporation

Kanegafuchi Kagaku Kogyo Kabushiki Kaisha

Hideo Kawachi

Yasuyoshi Ueda

Shiro Kitamura

Shun Wachi

Masanobu Tamura

Takuya Maeda

With respect to reduced coenzyme Q10, there has been no report about the presence of crystal polymorphism, and it has been considered that a conventionally obtained crystal form is only one form. The present invention relates to a reduced coenzyme Q10 crystal having an endothermic peak indicating melting at 54&#xb1;2&#xb0; C. during temperature rise at a rate of 5&#xb0; C./min by differential scanning calorimetry (DSC), and/or to a reduced coenzyme Q10 crystal showing characteristic peaks at diffraction angles (2&#x3b8;&#xb1;0.2&#xb0;) of 11.5&#xb0;, 18.2&#xb0;, 19.3&#xb0;, 22.3&#xb0;, 23.0&#xb0; and 33.3&#xb0; by powder X-ray (Cu&#x2014;K&#x3b1;) diffraction. The crystal form is a novel reduced coenzyme Q10 crystal which has a higher melting point and a lower solubility in a solvent, and is more excellent in stability than the conventionally known reduced coenzyme Q10 crystal.

Reduced coenzyme Q10 crystal having excellent stability

Provided is a production method of Form I crystal of reduced coenzyme Q10 or a crystalline solid thereof, which is substantially free of Form II crystal, including a step of holding a solution containing reduced coenzyme Q10 at a temperature exceeding 47&#xb0; C. for at least 60 minutes, and a step of crystallization thereafter.

Method for producing reduced coenzyme Q10

The present invention provides a method of separating ergosterol from a solution containing ergosterol in water-insoluble organic solvent, comprising supplying water to the solution and precipitating ergosterol. According to the method of the present invention, ergosterol crystals can be obtained at a high yield. Moreover, controlled water supply provides granular ergosterol aggregates exhibiting good solid-liquid separation character at a high yield.

Method of separating ergosterol

An isobutylene is polymerized in the presence of an aromatic initiator and a catalyst under the conditions that either a chlorinated hydrocarbon or an aromatic hydrocarbon is used singly or in admixture with an aliphatic hydrocarbon so that the reaction solution has a dielectric constant of 1 to 5 and a solubility parameter of 7.5 to 9.0.

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Hyogo, Japan

Hideo Kawachi