Kawasaki Jukogyo Kabushiki Kaisha

Nippon Steel Corporation

Sumitomo Chemical Company, Limited

Kawasaki Steel Corporation

Hideo Kaneko

Hatsuyoshi Kumashiro

Akira Iwata

Iwao Nakatsuka

Hiroyuki Nakashima

Shogo Matsumura

Koichiro Komai

Toshihiro Kosuge

Haruo Ohguro

Ryuuzou Hanzawa

Hiroyuki Kawai

Youji Ao

Hatuyoshi Kumashiro

Tsutomu Fujii

Eiji Inoue

Keikichi Murakami

Yoshiyasu Yabusaki

Toshiyuki Sakaki

Shoichi Hiwasa

Hiroshi Iwasaki

Koji Hayashi

Akira Murata

Yoji Ao

Sadaaki Murakawa

Taizou Kiyosuke

Yukio Morimoto

Kazuaki Sueoka

Katsuhiko Kawamoto

Satoshi Satoh

Shinji Shiraishi

Yoshikazu Nishi

Makoto Ueda

Toshio Iida

Kenichi Murai

There is disclosed a method for evaluation of the safety of a chemical compound, which includes the steps of: (a) reacting a chemical compound with recombinant yeast cells expressing, or in other words producing, human cytochrome P450 molecular species P450 1A2, P450 2C9, P450 2E1 and P450 3A4 together with a yeast NADPH-P450 reductase, which may be in the form of a fused enzyme with each of said human cytochrome P450 molecular species, or with the cell free extracts of the yeast cells; and (b) analyzing the resulting metabolite to determine the safety of the compound. According to this method, it can be determined whether a test compound will be converted into a carcinogenic or mutagenic form through the metabolism in the human liver, and whether the test compound or its metabolite has mutagenicity.

Method for safety evaluation of chemical compound using recombinant yeast expressing human cytochrome P450

Oligonucleotide for use in checking presence or absence of mutation in

A continuous casting apparatus comprises continuously supplying molten metal from a tundish to a cooled mold having an inlet and an outlet at least through a break ring, forming a cast section by continuously cooling the molten metal in the mold and starting the solidification of the molten metal below its surface, and intermittently withdrawing the cast section with respect to the mold through its outlet. During continuous casting, a sealing gas having a pressure higher than atmospheric and being soluble in the molten metal is invariable supplied to the entirety of the contact area of the mold and the break ring.

Apparatus for continuous casting

A horizontal continuous casting apparatus comprises, in one aspect, a tundish in which a molten metal material is stored, a mold assembly connected air-tightly to the tundish for casting a round billet, and an extraction device disposed on a downstream side of the mold assembly for forming a billet having a predetermined shape from the round billet fed from the mold assembly. The extraction device comprising a plurality of formation roll units arranged along a casting direction of the round billet and the formation roll units are composed of horizontal circular roll pairs, press units for pressing the roll pairs against the round billet and drive units for driving the roll pairs.

Method and apparatus for performing horizontal continuous casting

A continuous cast method comprises continuously supplying molten metal from a tundish through a break ring to a cooled mold having an inlet and an outlet. A cast section is formed by continuously cooling the molten metal in the mold and starting the solidification of the molten metal below its surface and intermittently withdrawing the cast section with respect to the mold through its outlet. During continuous casting, a sealing gas having a pressure higher than atmospheric and soluble in the molten metal is constantly supplied to the entirety of the contact area of the mold and the break ring.

Method and apparatus for continuous casting

In a method and apparatus for withdrawing a strand in a horizontal continuous casting installation, the strand is withdrawn from a mold by a predetermined stroke and then retracted by a smaller stroke corresponding to shrinkage of the strand. This cycle of withdrawal and retraction is repeated intermittently. A strand withdrawing and retracting characteristic of a cycle is set in a control unit, and pinch rolls for withdrawing and retracting the strand are controlled based on the set characteristic. Actual withdrawing and retracting strokes of the strand are detected by a detecting device and the detected signal is compared with the set characteristic to produce an instruction signal which is fed back to the pinch rolls, so that the positional accuracy of the strand and the quality of the strand are improved.

Method of and apparatus for withdrawing strand in horizontal continuous

Continuous casting facilities generally including a pair of moulds with a rail on each side thereof. Self-propelled tundish cars each carrying a tundish with a detachable immersion nozzle ride on the rails. The apparatus includes a truck running on the rail opposite the operator's side of the moulds connectable with one of the tundish cars and carrying an immersion nozzle exchanger. A connecting piece feeder, a powder feeder, and an immersion nozzle preheater are also mountable on the truck. Equipment interferences are eliminated by the specific structures and the operator's view of the moulds is not obstructed.

Labor saving apparatus for continuous casting facility

A horizontal continuous casting installation wherein a body of molten metal stored in a tundish is continuously fed through a tundish nozzle connected to the tundish near its bottom and extending horizontally to a mold connected to the forward end of the tundish nozzle coaxially therewith, to perform casting by the mold to produce a strand continuously withdrawn horizontally from the mold. An electromagnetic field generating device is arranged in the vicinity of the tundish nozzle and mold in a manner to enclose same, to generate an electromagnetic force oriented toward the center of a body of molten metal flowing through the boundary and exerted on the body of molten metal. The electromagnetic field generating device is constructed such that a magnetic flux of higher density is generated in a lower portion of the body of molten metal than in an upper portion thereof.

Horizontal continuous casting installation

A horizontal continuous casting installation, particularly for casting a strand of a large transverse dimension, wherein a body of molten metal stored in a tundish is continuously supplied through a tundish nozzle secured to the tundish in the vicinity of its bottom and extending horizontally therefrom to a mold connected to the forward end of the tundish nozzle and arranged coaxially therewith to cast a strand which is continuously withdrawn horizontally from the mold. The mold has an inner transverse dimension greater than the inner transverse dimension of the tundish nozzle. An electromagnetic field generating device is located between an outer surface of the tundish nozzle and an inner surface of the mold in the vicinity of an end surface of the mold facing the tundish nozzle for exerting an electromagnetic force on the body of molten metal flowing from the tundish nozzle to the mold in such a manner that the electromagnetic force is oriented toward the center of the body of molten metal.

A horizontal continuous casting method for continuously feeding a molten metal stored in a tundish through a tundish nozzle located in the vicinity of the tundish at its bottom to a mold horizontally connected to the tundish nozzle to produce a strand, wherein an electromagnetic field generating device is arranged in the vicinity of the boundary between the tundish nozzle and the mold for exerting an electromagnetic force directed toward a center of the molten metal flowing through the vicinity of the boundary or in a strand withdrawing direction, to separate the molten metal from the inner surface of the tundish mozzle anterior to the boundary with respect to the strand withdrawing direction, to allow the molten metal to come into contact with the inner surface of the mold posterior to the boundary with respect to the strand withdrawing direction. Control of the electromagnetic force exerted on the molten metal is effected by the electromagnetic field generating device arranged in the vicinity of the boundary in such a manner that a point at which the molten metal begins to come into contact with the inner surface of the mold coincides with a predetermined point. The electromagnetic force may also be controlled in such a manner that the points at which the molten metal begins to come into contact with the inner surface of the mold are brought to the same position peripherally of the molten metal with respect to the axis thereof.

Horizontal continuous casting method

For sampling, and/or measuring the temperature of, the molten metal within a furnace such as a steel converter, a probe is inserted into the furnace through an opening formed at or in the adjacency of its bottom. An inert gas, either singly or in combination with oxygen and a hydrocarbon gas such as propane, butane, and natural gas, is constantly blown into the furnace through the opening in order to prevent the influx of the molten metal.

Method and apparatus for probing into a refining furnace or the like for

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Kobe, Japan

Hideo Kaneko