Nihon Nohyaku Co., Ltd.

Sony Corporation

Pola Pharma Inc.

Teikoku Seiyaku Co., Ltd.

Hideo Kaneda

Takaaki Masuda

Hiroyasu Koga

Yasuko Nanjoh

Naotaka Kishi

Makoto Gotoh

Mamoru Naruse

Yoshiyuki Miyata

Tomohiro Ishima

Kazuo Kanai

Takashi Sekine

Shinichi Ota

Tomonari Yoshimura

Takehiko Ishiwata

Noboru Shiina

Takehito Ishiwata

Since treatment effects of conventional external preparations were not satisfactory, it is aimed to provide a novel external preparation that is excellent in drug permeability to nail, capable of fully exhibiting effects of an antifungal drug, and effective for treatments of diseases such as nail mycosis and nail candidiasis, particularly, treatments for nail tinea. The external preparation of this invention is a pharmaceutical composition for nail characterized by containing an antifungal drug, alkylpyrrolidone or a derivative thereof, and a crosslinking hydrogel.

Pharmaceutical composition for application to nail

An object is to provide a crystal having a new crystal habit of luliconazole and expand the possibility of application to pharmaceuticals. Disclosed is a crystal of luliconazole having such a crystal habit that (020) plane is a specific crystal growth surface. 

Crystal having specific crystal habit and pharmaceutical composition containing the crystal as active ingredient

Means for improving the solubility of luliconazole is provided. A crystal of luliconazole represented by the following formula is provided, wherein the crystal has such a crystal habit that (011) plane is a specific crystal growth plane. The crystal is characterized in that Iwith respect to a sum total of I, I, I, I, I, I, I, I, I, I, I, I, I, I, and Iis not less than 25%, provided that integrated intensities of diffraction peaks, which correspond to the (001), (100), (10-1), (011), (110), (11-1), (10-2), (11-2), (020), (021), (20-2), (121), (013), (11-3), and (221) planes, are designated as I, I, I, I, I, I, I, I, I, I, I, I, I, I, and Irespectively in relation to the diffraction peaks detected in a range of 2&#x3b8;=5 to 35&#xb0; in a powder X-ray diffractometry using CuK&#x3b1; radiation. 

Crystalline form having specific crystal habit and pharmaceutical composition containing this crystalline form as active ingredient

An object is to provide means for suppressing the formation of any isomer of luliconazole on account of any influence of, for example, the humidity and the light and improving the stability. Disclosed is a method for differential evaluating a crystal of luliconazole, comprising differential evaluating the crystal by using, as indexes, surface free energy of the crystal of luliconazole and a ratio of a polar component of the surface free energy, wherein the crystal is evaluated to be stable on condition that the surface free energy is smaller and the ratio of the polar component is lower.

Use of surface free energy for differential evaluation of crystal, crystal evaluated on basis of surface free energy as index, and pharmaceutical composition prepared by containing the crystal

The invention provides a method for the treatment of fungal dermatitis. The treatment method involves administering an effective amount of luliconazole or a pharmaceutically acceptable salt thereof to a target in need of a treatment of fungal dermatitis.

Agent for fungal dermatitis

The invention relates to a therapeutic agent for fungal dermatitis, containing luliconazole or a pharmaceutically acceptable salt thereof as an active ingredient, and a composition for the treatment of fungal dermatitis, containing luliconazole or lanoconazole in a substantially dissolved state as an active ingredient.

An electronic apparatus having a display function is able to alter the orientation of an image displayed on a display means for displaying images between a first orientation and a second orientation different from the first orientation. A plurality of operating means are provided at positions symmetrical between disposal positions which take the first orientation as a standard orientation and disposal positions which take the second orientation as a standard orientation.

Tilt direction detector for orienting display information

A speaker system has a laterally extending body portion for supporting the back of the head of a user and a pair of right and left side portions respectively connected to the right and left ends of the body portion. A plurality of openings in side wall of each of two speaker boxes for making communication between the inside and the outside of each speaker box, for preventing sound leakage from each speaker unit and ensuring the sound pressure level in a low-frequency range of the audio frequencies reproducible by the speaker unit.

Speaker system with a plurality of openings in side walls of each of two speaker boxes

Disclosed herein is a music stand including, a music paper receiving frame, and a suction cup device configured to support said music paper receiving frame.

Growing community of inventors

Tokyo, Japan

Hideo Kaneda