Canon Kabushiki Kaisha

Hidenori Shiotsuka

Ichiro Kataoka

Satoru Yamada

Takahiro Mori

Ayako Komori

Takeshi Imamura

Junta Yamamichi

Shigeo Kiso

Hideaki Zenko

Akiharu Takabayashi

Izumi Kumagai

Ayako Shiotsuka

Tsuyoshi Nomoto

Satoru Hatakeyama

Tomohiro Yamada

Tetsunori Ojima

Masaru Kaieda

Ryo Kuroda

Tsutomu Murakami

Takehito Yoshino

Koichi Shimizu

Yoshifumi Takeyama

Takeshi Takada

Koji Tsuzuki

Miki Ogawa

Masaya Ogino

Kazuhiro Ban

Satoru Nishiuma

Ichiro Kataoya

Sigeo Kiso

A substrate of a target substance detection element to be used for a detection apparatus for detecting a target substance, utilizing surface plasmon resonance, comprises a base and a metal structure arranged on the surface of the base in a localized manner or a metal film having an aperture and arranged on the surface of the base, the metal structure or the aperture, whichever appropriate, having at least either of a loop section and a crossing section.

Substrate of target substance detection element to be used in apparatus for detecting target substance by utilizing surface plasmon resonance and detection element and detection apparatus using same

A target substance detecting device, which is a device that has a substrate, a structure disposed on a substrate surface in isolation using a metal, and a target substance trapping substance disposed on the structure, and which is for detecting a target substance using localized plasmon resonance, characterized in that the above-mentioned structure is constructed by stacking at least two metal layers, sandwiching a non-conductive layer between the metal layers.

Target substance detecting device, target substance detecting method using the same, and detecting apparatus and kit therefor

A capturing molecule having an association containing a plurality of polypeptide chains that specifically bind to different sites of a target substance, characterized in that each of the polypeptide chains has a domain having a hypervariable loop structure at a binding site binding to the target substance and an association portion for forming the association, and the polypeptide chains are associated via the association portions present in the polypeptide chains.

Bispecific capturing molecule

The invention provides an organic material-immobilizing structure employing new immobilization means, characterized in that at least a part of the surface of the substrate is comprised of one or more members containing silicon oxide, the organic material is bound to the surface of the substrate through a binding domain bound to the organic material and containing an amino acid sequence capable of binding to silicon oxide, selected from the group consisting of amino acid sequences of SEQ ID NOS: 1 and 2: Val-Ser-Pro-Met-Arg-Ser-Ala-Thr-Thr-His-Thr-Val; and Ile-Pro-Met-His-Val-His-His-Lys-His-Pro-His-Val, and derivatives thereof.

Organic material-immobiling structure and method for production of the same, and peptide and DNA therefor

A substrate for forming a target substance detecting device includes a supporting member, an underlying layer disposed on a surface of the supporting member, and a metal pattern layer, disposed on a surface of the underlying layer, for being bound to a target substance trapping substance capable of trapping a target substance in a specimen solution at least containing water as a liquid medium to detect the target substance by utilizing plasmon resonance. The underlying layer has a refractive index nb satisfying the following relationship:0.90 na&#x2266;nb&#x2266;1.05 na,wherein na represents a refractive index of water.

Substrate for target substance detecting device, target substance detecting device, target substance detecting apparatus and method using the same, and kit therefor

A capturing molecule having not less than two domains specifically binding to different sites of a target substance, wherein the not less than two domains comprise (1) a first domain having a hypervariable loop structure at a binding site to the target substance, and (2) a second domain having no hypervariable loop structure at a binding site to the target substance.

Target substance capturing molecule

A protein utilizing an anti-gold antibody and a gold-binding side which is a part of the anti-gold antibody is constructed. This protein is capable of specifically binding to gold. This protein or a complex protein containing such a protein can be used for the detection of a target substance.

Gold-binding protein and use thereof

It is intended to provide an anti-photocrosslinking group antibody capable of specifically binding to a photocrosslinking group and available in the binding of a substrate and a substance of interest in a microstructure, a complex protein including at least the antibody or at least a portion thereof, and a technique for use thereof in the detection of a target substance. The present invention provides a protein having at least the structure of an antibody that recognizes a photocrosslinking group.

Protein, method for immobilizing protein, structure, biosensor, nucleic acid, vector and kit for detecting target substance

A structure comprises at least a porous body holding a substance releasably, comprising a capping member for keeping the substance inside the pore and/or on at least a part of the entire surface of the porous body, and a connecting member for connecting the porous body and the capping member separably, the connecting member comprising a biopolymer compound. A method for releasing a substance from the structure set forth comprises the steps of applying stimulation from outside to the structure, and cleaving at least one of the bonding between the connecting member and the capping member and the bonding between the connecting member and the porous member to make the substance releasable from the structure.

Structure and method for releasing substance therefrom

There is disclosed a method of producing a solar cell module comprising the steps of: mounting a body to be laminated onto a tabular member, carrying in the body to be laminated along with the tabular member onto a heated mounting board; heat-bonding the body to be laminated by pressing with an expanding unit; carrying out the body to be laminated along with the tabular member from the mounting board after parting the expanding unit from the body to be laminated; and separating the body to be laminated from the tabular member. By using the method, a temperature of the body to be laminated does not increase rapidly and a foaming phenomenon is suppressed, thereby allowing manufacturing of the solar cell module with a high yield.

Method of producing solar cell module

It is intended to provide a target substance-capturing body comprising: a base consisting of a soluble protein; and two or more functional domains capable of binding to different target substances.

Device for capturing target substance

To provide an organic substance-immobilized structure employing a novel immobilizing technique and a manufacturing method thereof using the novel immobilizing technique, where, when an organic substance, particularly a biological substance is immobilized on the surface of a substrate, the organic substance, particularly the biological substance can be stably immobilized on the surface of the substrate through orientation of the organic substance, particularly the biological substance suitable for exerting physiological functions thereof. At least part of the substrate's surface is constructed of one or more substrates containing aluminum oxide. The immobilization of the organic substance to the surface of the substrate is carried out by binding at least part of the binding domain to the surface of the substrate through a binding domain containing a peptide having an affinity to aluminum oxide and composed of at least one or more amino acids, which is coupled with the organic substance.

Growing community of inventors

Kawasaki, Japan

Hidenori Shiotsuka