Fujisawa Pharmaceutical Company, Ltd.

Astellas Pharma Gmbh

Wakunaga Pharmaceutical Co., Ltd.

Hidenori Ohki

Kohji Kawabata

Hisashi Takasugi

Akira Yamada

Masaki Tomishima

Toshio Yamanaka

Keiji Matsuda

Satoshi Inoue

Shinya Okuda

Kenji Murano

Takashi Tojo

Kenji Itoh

Ayako Toda

Nobuyuki Shiraishi

Keiji Misumi

Hiroshi Matsuda

Shigehiro Takase

Hiroshi Hatanaka

Seiji Hashimoto

Yasuhisa Tsurumi

Kazutoshi Sakamoto

Hiroaki Mizuno

David Barrett

Takahiro Matsuya

Kenji Satoh

Kazuo Sakane

Masakuni Okuhara

Takashi Ogino

Yasuhiro Hori

Nobuharu Shigematsu

Chiyoshi Kasahara

Motohiro Hino

Takuya Makino

Shigeki Kunikawa

Norio Hashimoto

Hiroaki Ohtake

Junya Ishida

Akihiko Fujie

Atsushi Kanda

Michizane Hashimoto

Masaharu Ichihara

Yu Harayama

Toshiro Iwamoto

Kumiko Nitta

Atsushi Ohigashi

Tomomi Takezawa, Legal Representative

Masaru Oogaki

Kenji Sato

Hitomi Ogino, Legal Representative

Tetsuya Ogino, Legal Representative

Hisashi Akamatsu

Ryuichi Kanasaki

Masaru Ohgaki

The present invention relates to a new cyclic peptide compound or a salt thereof, which has anti-hepatitis C virus activities based on inhibitory activity against the RNA replication of hepatitis C virus replicon, a process for preparation thereof, a pharmaceutical composition comprising the same, and a method for prophylactic and/or therapeutic treatment of hepatitis C in a human being or an animal.

Cyclic peptide compounds

The present invention relates to a compound of the formula [I]:  

Cephem compounds

The present invention relates to a compound of the formula [I]: wherein A is lower alkylene or lower alkenylene; Ris lower alkyl, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, amino(lower)alkyl or protected amino(lower)alkyl, and Ris hydrogen or amino protecting group, or Rand Rare bonded together and form lower alkylene; Rand Rare independently amino or protected amino; and Ris carboxy or protected carboxy, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.

The present invention relates to a compound of the formula [I]: wherein 

This invention relates to new polypeptide compound represented by general formula (I), wherein R, R, R, R, Rand Rare as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on &#x3b2;-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases includinginfection (e.g.pneumonia) in a human being or an animal.

Cyclic hexapeptides having antibiotic activity

Cyclohexapeptides having antimicrobial activity

The invention relates to new polypeptide compounds represented by the following formula &lsqb;I&rsqb;:

Echinocandine derivatives with antimicrobial activity

This invention relates to new polypeptide compounds represented by the following formula (I):

This invention relates to new polypeptide compounds represented by general formula (I), wherein R,, R,, R,and R,are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on &bgr;-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases including,infection (e.g.,pneumonia) in a human being or an animal.

Cyclic hexapeptides with antimicrobial activity

A process for preparing a polypeptide compound having antimicrobial activities of the following general formula: ##STR1## wherein R.sup.1 is hydrogen

Polypeptide compound and a process for preparation thereof

A polypeptide compound having antifungal activities of the following general formula: ##STR1## wherein R.sup.1 is hydrogen R.sup.2 is acyl group,

A polypeptide compound having antimicrobial activity of the following general formula: ##STR1## wherein R.sup.1 is hydrogen or acyl group, R.sup.2 is hydroxy or acyloxy,

Growing community of inventors

Osaka, Japan

Hidenori Ohki