Sumitomo Dainippon Pharma Co., Ltd.

Sumitomo Pharma Co., Ltd.

Dainippon Sumitomo Pharma Co., Ltd.

Hidenori Kimura

Yoshiaki Isobe

Hitoshi Watanabe

Hitoshi Ban

Yuji Fujiwara

Hiroyuki Nakahira

Yohei Ikuma

Nobuhisa Fukuda

Kozo Yoshida

Junya Ikeda

Kiyoto Sawamura

Masato Iwata

Satoshi Suetsugu

Yoshio Nakai

Kuniko Suzuki

Akira Fusano

Hitoshi Hochigai

The present invention provides a compound of the formula (1):

Substituted pyrimidines as vaccine adjuvants

The present invention provides a compound of the formula (1): wherein X, R, R, R, R, R, R, Y, Y, L, and m are as defined in the description, and a pharmaceutically acceptable salt thereof, which are useful as a vaccine adjuvant.

The present invention provides a compound of formula (1) and a pharmaceutical composition comprising the compound useful as a nerve regeneration promoter wherein R-L- is R&#x2014;OC(O)&#x2014;, or the like, Ris hydrogen atom, optionally-substituted Calkyl group, optionally-substituted 3- to 8-membered cycloalkyl group, or the like, Ris hydrogen atom or the like, Ring A is formula (2) or formula (3) wherein Ris hydrogen atom, optionally-substituted Calkyl group, or the like, the part of X, Y, and Z is X&#x2550;Y&#x2014;Z, X&#x2014;Y&#x2550;Z, or X&#x2014;Y&#x2014;Z, X is nitrogen atom, NR(Ris hydrogen atom, optionally-substituted Calkyl group, or the like), or the like, Y is carbon atom or the like, and Z is carbon atom, nitrogen atom or the like.

Biheterocyclic compound

The present invention provides a compound of the formula (2): 

Pyrimidine compounds and their use as vaccine adjuvants

A compound represented by formula (1) (in the formula: ring-D represents a three- to eight-membered hydrocarbon ring; Rrepresents an optionally substituted amino Calkyl group or the like; Rand Reach independently represent a hydrogen atom, a halogen atom, or the like; Rrepresents an optionally substituted Caryl group or the like; Rrepresents a hydrogen atom or the like; and ring-Q represents a (hetero)aryl group or the like which may be substituted with a carboxyl group or the like) or a pharmaceutically acceptable salt thereof exhibits an excellent FXIa inhibitory activity, and is useful as a therapeutic agent against thrombosis or the like. 

1-(cycloalkyl-carbonyl)proline derivative

The present invention relates to a compound of the following formula (I) or a pharmaceutically acceptable salt thereof, being useful as a renin inhibitor. [wherein Ris halogen, etc.; Ris H, etc.; Gis &#x2014;N(R)&#x2014;, etc.; Gis &#x2014;CO&#x2014;, etc.; Gis &#x2014;C(R)(R)&#x2014;, etc.; Gis oxygen, etc.; Ris optionally substituted Calkyl, etc.; Rand Rare independently the same or different, H, etc.; Ris H, optionally substituted Calkyl, etc.; R, R, Rc and Rare independently the same or different, and a group: -A-B (said A is single bond, etc., and said B is H, etc.), etc.; and n is 1, etc.]

Bicyclic heterocyclic derivative

Compounds represented by the general formula (I), prodrugs thereof, or pharmaceutically acceptable salts of both are provided as compounds which have high DPP-IV inhibiting activity and are improved in safety, toxicity and so on: (I) wherein the solid line and dotted line between Aand Arepresents a double bond (A&#x2550;A) or the like; Ais C(R) or the like; Ais nitrogen atom or the like; Ris hydrogen atom, optionally substituted alkly group, or the like; Ris hydrogen atom, optionally substituted alkyl group, or the like; Ris hydrogen atom, halogen atom, or the like; Ris hydrogen atom, hydroxyl, halogen atom, or the like; and Y is a group represented by the general formula (A) or the like; (A) [wherein m1 is 0, 1, 2 or 3; and the group (A) may be freed from Ror substituted with one or two R's which are each independently halogen atom or the like.]

Growing community of inventors

Tokyo, Japan

Hidenori Kimura