Fujifilm Corporation

Hidenobu Kuniyoshi

Hideyasu Fujiwara

Takashi Tamura

Daisuke Nakagawa

Hiyoku Nakata

Takuya Matsumoto

Shinsuke Mizumoto

Yuji Yoshimitsu

Yasutaka Baba

Mari Yamamoto

Yohei Kubo

Shinji Hagiwara

Takayuki Ito

Hideki Okada

Toru Watanabe

Kazuhiro Aikawa

Yuichiro Sato

Tomoyuki Mashiko

Takehiro Yamane

Shintaro Tanabe

Kimihiko Sato

Takayuki Yamakawa

Hideki Kurihara

Eiichi Kodama

An object of the present invention is to provide a compound exhibiting an excellent drug efficacy as an anti-adenoviral agent, and an anti-adenoviral agent. The present invention provides a compound represented by General Formula [1]

Cyclobutyl purine derivative or salt thereof

Disclosed are a compound and a pharmaceutical composition that exhibit an excellent drug efficacy against a tumor, in particular a tumor which has acquired resistance to gemcitabine. Specifically, provided is a thionucleoside derivative represented by General (in the formula, Rrepresents a hydroxyl group which may be protected, a Calkoxy group which may be substituted, or the like; Rrepresents a Calkoxy group which may be substituted, a Ccycloalkoxy group which may be substituted, or the like; and Rrepresents a hydrogen atom or the like); or a salt thereof. Further, provided is a pharmaceutical composition containing such a thionucleoside derivative or a salt thereof.

Thionucleoside derivative or salt thereof, and pharmaceutical composition

Disclosed are a compound and a pharmaceutical composition that exhibit an excellent drug efficacy against a tumor, in particular a tumor which has acquired resistance to gemcitabine. Specifically, provided is a thionucleoside derivative represented by General Formula [1] 

There is provided a production method of a compound represented by the following formula (II) through a step of reacting a compound represented by the following General Formula (I) with a sulfur compound.  In General Formulas (I) and (II), Rrepresents a hydrogen atom or an acyl group, Rrepresents a hydrogen atom, a fluorine atom, an acyloxy group, an arylmethyloxy group, an allyloxy group, an arylmethyloxycarbonyloxy group, or an allyloxycarbonyloxy group, Rrepresents a hydrogen atom or an acyloxy group, Rrepresents an alkyl group or an aryl group, and X represents a leaving group. Here, in a case where Ris a fluorine atom, an acyloxy group, an arylmethyloxy group, an allyloxy group, an arylmethyloxycarbonyloxy group, or an allyloxycarbonyloxy group, Ris an acyloxy group.

Method for producing thiolane skeleton-type glycoconjugate, and thiolane skeleton-type glycoconjugate

The object of the present invention is to provide a compound and a pharmaceutical composition having excellent Syk inhibitory activity. According to the present invention, a nicotinamide derivative represented by the following formula (I) or a salt thereof is provided, wherein (wherein R, R, R, n, and Xhave the same definitions as those described in the specification), and Ris a pyridyl, indazolyl, phenyl, pyrazolopyridyl, benzisoxazolyl, pyrimidinyl, or quinolyl group, each of which optionally has at least one substituent.

Nicotinamide derivative or salt thereof

An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. The present invention provides a nicotinamide derivative represented by the following formula (I) (wherein Rrepresents a halogen atom; Rrepresents a Calkyl group, a Calkenyl group, a Calkynyl group, a Ccycloalkyl group, an aryl group, an ar-Calkyl group or a heterocyclic group, each optionally having at least one substituent; Rrepresents an aryl group or a heterocyclic group each optionally having at least one substituent; and Rand Reach independently represent a hydrogen atom; and Rand Rmay form a cyclic amino group optionally having at least one substituent together with the nitrogen atom to which they bind) or a salt thereof, and a pharmaceutical composition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.

A compound having superior solubility and suitable for a liposome contrast medium selective for a lesion such as vascular diseases is provided which is represented by the following general formula (I) wherein R, Rand Rindependently represent an alkyl group or an alkenyl group having 8 to 25 carbon atoms; X represents &#x2014;O&#x2014;, or &#x2014;N(Z)&#x2014; (Z represents hydrogen atom, or an alkyl group having 1 to 3 carbon atoms); and L represents a divalent bridging group constituted by atoms selected from the group consisting of carbon atom, hydrogen atom, oxygen atom, nitrogen atom and sulfur atom; Ch represents a functional group represented by the following general formula (II), and in the general formula (II), any one of the hydrogen atom H, H, H, H, H, and His substituted with L. 

Higher fatty acid triester compound having diethylenetriamine-type metal chelate structure

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Ashigarakami-gun, Japan

Hidenobu Kuniyoshi