Yamanouchi Pharmaceutical Company Ltd.

Hidemi Shimizu

Jun Sekino

Kiyoshi Okazaki

Masuo Murakami

Shigemi Kawahara

Hiroitsu Kawata

Hiroitsu Kawada

Tadayoshi Ohmura

There is disclosed a dry, stabilized oral pharmaceutical formulation containing a prostaglandin E group prepared from a lyophilized composition comprising a prostaglandin E group and at least a member selected from the group consisting of a thiol compound, dextrin, dextran, a lower alkyl cellulose, and a water-soluble salt of deoxycholic acid.

Stabilized oral prostaglandin formulation and the process for the

There is provided a process of preparing a prostaglandin E group-containing formulation by adding to a prostaglandin E group at least one additive selected from the group consisting of thiol compound, a water-soluble high molecular weight compound, and a water-soluble salt of deoxycholic acid and then subjecting the mixture to lyophilization.

Process of preparing stable prostaglandin E group-containing formulation

A dried and stabilized prostaglandin composition containing a prostaglandin E group compound with calcium lactate and/or amylopectin, and a stabilized pharmaceutical preparation for practical administration prepared from the said composition.

Stabilized prostaglandin composition and the process for the preparation

There is provided a process of preparing a prostaglandin E group-containing formulation by adding to a prostaglandin E group at least one additive selected from the group consisting of a thiol compound, a water soluble high molecular weight compound and a water-soluble salt of deoxycholic acid and then subjecting the mixture to lyophilization.

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Ageo, Japan

Hidemi Shimizu