Daiichi Sankyo Company, Limited

Hideko Hoh

Atsushi Nakayama

Shin Iimura

Nobuo Machinaga

Jun Chiba

Yoshiyuki Yoneda

Fumihito Muro

There is provided a VLA-4 inhibitory drug having good oral absorbability and exhibiting sufficient anti-inflammatory effects when administered orally. A compound represented by the following formula (I): wherein Rrepresents a hydrogen atom or a C1-8 alkyl group; Rrepresents a hydrogen atom, a halogen atom, a C1-8 alkoxy group, or a benzyloxy group which may be substituted; Q represents a monocyclic or bicyclic nitrogen-containing heterocyclic group which may be substituted, and has a nitrogen atom as the bonding site; Y represents an oxygen atom or CH; W represents a bicyclic aromatic hydrocarbon ring group which may be substituted, or a bicyclic aromatic heterocyclic group which may be substituted; R, Rand Reach independently represent a hydrogen atom, a halogen atom, a C1-8 alkoxy group or a C1-8 alkyl group; and Arepresents a nitrogen atom or C&#x2014;R(wherein Rrepresents a hydrogen atom, a halogen atom, a C1-8 alkoxy group or a C1-8 alkyl group),

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Edogawa-ku, Japan

Hideko Hoh