Toa Eiyo Ltd.

Hideki Yamada

Shin-ichi Kazayama

Atsuo Takahashi

Hidekazu Masaki

Takeshi Hasegawa

Fumiya Yoneyama

Takahiro Morita

Tetsuo Kuze

Shoji Satoh

Yusuke Mizuno

Mizuo Miyazaki

Akira Tatsui

Shinji Takai

Koichi Takayanagi

Shin-ya Ohnuma

The present invention relates to an N-substituted benzothiophenesulfonamide derivative or a pharmaceutically acceptable salt thereof and applications thereof. Furthermore, it provides an agent for preventing or treating cardiac or circulatory disease and so on caused by abnormal increase of production of angiotensin II or endothelin I based on chymase activity, or by activation of mast cell, and an agent for preventing adhesion after surgery, wherein the agent has a selective inhibitory action on chymase.

N-substituted benzothiophenesulfonamide derivatives

A halogenobenzylaminopropionic acid derivative represented by the following formula (1):or a pharmaceutically acceptable salt of the derivative, and a drug containing the same as an active ingredient for treating diabetes, hyperlipidemia, or similar pathological conditions.

Halogenobenzyl aminopropionic acid derivatives

Growing community of inventors

Saitama, Japan

Hideki Yamada