Mitsubishi Tanabe Pharma Corporation

Wyeth

Hideki Ushirogochi

Takao Abe

Aranapakam Mudumbai Venkatesan

Atul Agarwal

Koichi Sato

Wataru Sasaki

Fumihiko Akahoshi

Ryo Sakakibara

Yuichi Onda

Fuk-Wah Sum

Tarek Suhayl Mansour

Yansong Gu

Satoshi Tamai

Ado Mihira

Tetsuo Yamaguchi

Tsuyoshi Takasaki

Hiroyuki Kawanishi

Tatsuyuki Takahashi

Tohru Takebe

Minami Yamaguchi

Hiroshi Matsunaga

Chisato Sato

A compound represented by general formula [I] wherein X represents N or the like, Y represents CH or the like; Rrepresents a cycloalkyl group which may be substituted or the like, Rrepresents an alkyl group or the like, Rrepresents an alkyl group which may be substituted or the like, Rrepresents a hydrogen atom or an alkyl group, or a pharmaceutically acceptable salt thereof has an inhibitory activity on aldosterone synthetase, and is useful as a prophylactic and/or therapeutic agent for various diseases or symptoms associated with aldosterone.

Nitrogen-containing aromatic heterocyclic compound

This invention provides a novel disubstituted 1,2,4-triazine compound or a pharmaceutically acceptable salt thereof, which has an aldosterone synthetase inhibitory activity and is useful for preventing and/or treating various diseases or conditions associated with aldosterone; a method for preparing it; use of it; as well as a pharmaceutical composition comprising it as an active ingredient. A compound of the general formula [I]: wherein Ris, for example, a group of the following formula (A-1): wherein ring Ais, for example, a cycloalkyl group which may be substituted,and Ris, for example, a monocyclic cycloalkyl group,or a pharmaceutically acceptable salt thereof.

Disubstituted 1, 2, 4-triazine compound

This invention provides a novel disubstituted 1,2,4-triazine compound or a pharmaceutically acceptable salt thereof, which has an aldosterone synthetase inhibitory activity and is useful for preventing and/or treating various diseases or conditions associated with aldosterone; a method for preparing it; use of it; as well as a pharmaceutical composition comprising it as an active ingredient. A compound of the general formula [I]: wherein Ris, for example, a group of the following formula (A-1): wherein ring Ais, for example, a cycloalkyl group which may be substituted, and Ris, for example, a monocyclic cycloalkyl group,or a pharmaceutically acceptable salt thereof.

A compound of the formula: wherein ring X is benzene or pyridine; Ris substituted alkyl; Ris optionally substituted aryl or optionally substituted heterocyclic group; Ris hydrogen or alkyl; Ris hydrogen, halogen or alkyl; Ris hydrogen or alkyl; Rand Rare the same or different and each hydrogen or halogen, or a pharmaceutically acceptable salt thereof, which is useful as Iblocker effective for preventing or treating cardiac arrhythmia such as atrial fibrillation.

Indazole acrylic acid amide compound

The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof, 

Tricyclic 6-alkylidene-penems as &#x3b2;-lactamase inhibitors

The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.wherein one of A and B denotes hydrogen and the other an optionally substituted fused tricyclic heteroaryl group; and X is S.

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Osaka, Japan

Hideki Ushirogochi