Sumitomo Chemical Company, Limited

Hideki Ushio

Takayuki Higashii

Masayoshi Minai

Isao Kurimoto

Akihiko Nakamura

Motoo Hazama

Miyuki Oikawa

Tsutomu Matsumoto

Shinzo Seko

Naoyuki Takano

Yasunobu Miyamoto

Hiroaki Fujishima

Atsushi Furutani

Takashi Miki

Yukihiro Honda

Hirokazu Murata

Etsuko Fukuda

Masahiko Mizuno

Yukari Fujimoto

Kazuhiro Yamauchi

Hiroaki Hibino

Toshikazu Yagi

Takayuk Higashii

Takahiro Kotera

Hiroshi Sogabe

Katsuichi Yasunaga

There is disclosed an advantageous mixed acid anhydride production method of formula (1):RC(O)OY(O)(R)&#x2003;&#x2003;(1)wherein R, Rand Y denote the same as defined below, n and p denote an integer of 1 or 2, which is characterized by adding a carboxylic acid of formula (2);RCOOH&#x2003;&#x2003;(2)wherein Rdenotes a hydrogen atom, an optionally substituted alkyl group or the like, an organic base to a solution of a carboxylic acid activating agent of formula (3);(R)Y(O)X&#x2003;&#x2003;(3)wherein Rdenotes an optionally substituted aliphatic hydrocarbyl group or the like, Y denotes a carbon atom, a phosphorus atom, or a sulfur atom, and X denotes a chlorine atom or the like.

Production of mixed acid anhydride and amide compound

There are disclosed imine compounds of formula (7) and (11), and processes for preparing the same:

Process for producing optically active 3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid, and salt thereof

Process for producing optically active 3,3,3-Trifluoro-2-Hydroxy-2-Methylpropionic acid, and salt thereof

Method for purifying pyruvic acid compounds

There is disclosed a method for producing an essentially enantiomerically pure N-protected-azetidine-2-carboxylic acid of formula (1):

Methods for producing N-protected-azetidine-2-carboxylic acids

There are disclosed an industrially favorable process for producing a tetrazole compound of general formula (1):

Production process and intermediate of tetrazole compound

The present invention provides a process for preparing optically active azetidine-2-carboxylic acids using readily available reagents of relatively low price in the industry. Thus, there is provided optically active azetidine-2-carboxylic acid, and a process for producing the same by subjecting optically active N-(alkylbenzyl)azetidine-2-carboxylic acid represented by the formula (1): ##STR1## to hydrogenolysis in the presence of a catalyst.

Process for producing optically active azetidine-2-carboxylic acid

A 1-bromoalkylbenzene derivative is prepared by reacting a phenylalkene derivative with hydrogen bromide in the presence of a non-polar solvent. The phenylalkene derivative is prepared by reacting an alkenyl halide with metal magnesium to form a Grignard reagent, and then reacting the Grignard reagent with a benzyl halide derivative. An allyl Grignard reagent is prepared by reacting continuously an allyl halide derivative with metal magnesium in an organic solvent, in which the allyl halide derivative and metal magnesium are continuously added to the reaction system and the allyl Grignard reagent formed is continuously removed from the reaction system. The processes provide the intended compounds in high yields, high selectivities and high purities.

Process for preparing 1-bromoalkylbenzene derivatives and intermediates

The present invention concerns a process for producing crystals of 3-amino-2-hydroxyacetophenone salt having a high bulk density and improved flow properties, by treating 3-amino-2-hydroxyacetophenone of formula (1) ##STR1## or hydrogen halide salt thereof with sulfuric acid, in a solvent.

Process for producing improved crystals of 3-amino-2-hydroxyacetophenone

3-�4-(4-Phenyl-1-butoxy)benzoyl!amino-2-hydroxyacetophenone is prepared by reacting a benzoate ester with a halobutylbenzene in the presence of a basic compound and an aprotic polar compound in an aromatic hydrocarbon solvent to obtain a corresponding ether, alkali hydrolyzing the ether in an aromatic hydrocarbon solvent and precipitating a hydrolysate with an acid to obtain 4-(4-phenyl-1-butoxy)benzoic acid, reacting a halogenating agent with this benzoic acid derivative in an aromatic hydrocarbon solvent to obtain an acid halide, and reacting the acid halide in an aromatic hydrocarbon solvent with a corresponding aromatic amine.

Process for preparing aromatic amide compound

Growing community of inventors

Takatsuki, Japan

Hideki Ushio