Terumo Kabushiki Kaisha

Hideki Uchiyama

Junji Kimura

Ryoichi Nanba

Hideto Ushijima

Hiroaki Kasukawa

Kazuo Kawahara

Eiko Takeda

Junichirou Watanabe

This invention provides a liposome having a drug included therein, which has active targeting property and ensured stability in blood and can be used effectively in the diagnosis and/or treatment of diseases, particularly renal diseases, that accompany production of proteoglycan, comprising (1) a basic compound which takes positive charge within a physiological pH range, (2) a lipid derivative of a hydrophilic polymer and (3) a lipid which constitutes the liposome, as its membrane constituting components, wherein their constituting ratios are from 1 to 20 mol % of (1) based on (3) and from 0.2 to 5 mol % of (2) based on the total of (1) and (3).

Liposomes

This invention relates to sulfonates of .beta.-cyclodextrin polymer having a sulfur content of 10% or more, which inhibit propagation of smooth muscle cells.

Sulfonated compounds of .beta.-cyclodextrin polymer and inhibitory drug

Growing community of inventors

Kanagawa, Japan

Hideki Uchiyama