Eisai Company, Limited

Eisai Inc.

Hideki Ono

Takeshi Suzuki

Kouichi Katayama

Isao Yamatsu

Shinya Abe

Kouji Yamada

Manabu Murakami

Akiharu Kajiwara

Kouji Nakamoto

Hajime Tsunoda

Toshihiko Kaneko

Shigeru Souda

Yoshimasa Machida

Shigeki Hibi

Seiichiro Nomoto

Katsuya Tagami

Yasushi Okamoto

Makoto Okita

Hiroshi Shirota

Kenichi Chiba

Ryoichi Hashida

Masayuki Tanaka

Hideto Ohhara

Masaki Goto

Hideki Sakurai

Tadashi Sato

Satoru Tanaka

Tsuneo Wakabayashi

Issei Ohtsuka

Toshiharu Ohgoh

Toshinobu Kunii

Mayumi Kawase

Kengo Kagei

Kouichiro Ueda

Isao Yamatsa

Naphthalene derivatives of the formula: ##STR1## wherein R.sup.1, represents a hydrogen atom, a lower alkyl group or an acyl group; R.sup.2 independently represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a cycloalkyl group, a cycloalkylalkyl group, a hydroxyl group, an aryl group which may be substituted, an arylalkyl group whose aryl group may be substituted, a heteroaryl group, or a heteroaryllakyl group; R.sup.3 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, an aryl group which may have a substituent, an arylalkyl group whose aryl group may be substituted, an arylalkenyl group whose aryl group may be substituted, a cycloalkyl group, an alkoxyalkyl group, a heteroaryl group, a heteroarylalkyl group, a carboxyl group, a carboxyalkyl group, an aminoalkyl group, or a cyano group; R.sup.6 is C.sub.1-6 alkyl; and m is 0 or an integer of from 1 to 2 useful in treating autoimmune diseases are disclosed.

Naphthalene derivative

A naphthalene derivative having the formula is new and useful for medicine. ##STR1## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an acyl group;

A naphthalene derivative having the formula is new and useful for medicine. ##STR1## [wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an acyl group;

Novel hydantoin derivatives and salts thereof, the process for the preparation thereof, and medicines containing the same, wherein the hydantoin derivatives are represented by the general formula: ##STR1## wherein X.sub.1 and X.sub.2, which may be the same or different, mean independently hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; Y means oxygen atom or sulfur atom, R.sub.1 and R.sub.2, which may be the same or different, mean independently hydrogen atom, a lower alkyl group or phenyl group, or the both may form a ring with a carbon atom which is combined with them, excluding the case wherein both R.sub.1 and R.sub.2 are hydrogen atom at the same time, and n means an integer of 0 or 1. The novel hydantoin derivatives and salts thereof have excellent effects for the treatment of the complications of the diabetes mellitus.

Hydantoin derivatives and medicines containing the same

Dolichol or phosphate thereof is useful as a therapeutically treating and preventive agent, in particular, for hyperuricuria, hyperlipemia, diabetes and hepatic diseases.

Therapeutic and preventive agent containing dolichol

Hydantoin derivatives and salts thereof, the process for the preparation thereof, and medicines containing the same, wherein the hydantoin derivatives are represented by the general formula: ##STR1## wherein the substituents are defined hereinbelow. The hydantoin derivatives and salts thereof have excellent effects for the treamtment of the complications of the diabetes mellitus.

Hydantoin derivatives for treating complications of diabetes

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Sakura, Japan

Hideki Ono