Kabushikikaisha Equos Research

Stella Pharma Corporation

Mitsubishi Chemical Corporation

Osaka Prefecture University Public Corporation

Stella Chemifa Corporation

Kabushiki Kaisha Toyota Jidoshokki

Stella Pharma Corporation; Osaka Prefecture University Public Corporation

University Public Corporation Osaka

Hideki Nakashima

Mitsunori Kirihata

Kohki Uehara

Hiroshi Takenaka

Yoichiro Ohta

Yuko Ishino

Sayuri Ueda

Yusuke Taguchi

Takashi Fujii

Shuzo Moroto

Tetsuo Nishida

Megumi Tomisaki

Kazuhiko Shogami

Hirofumi Suzuki

Takahiro Iwami

Tomohiro Yoshikawa

Kozo Yamaguchi

Hirohisa Kikuyama

Masao Kawai

Masahide Waki

Hideki Aruga

Kazushi Kamiya

Mitsugi Yamashita

Takanobu Kujime

Rui Hasebe

Hisanori Shirai

Keiichi Nii

Kanenori Ito

Hitoshi Tsurumaru

Nobuaki Kawabata

Yoshimitsu Katakuse

Yoshiya Iguchi

Yoshikazu Yamauchi

Mitsugi Yamasita

Kenichiro Kawaguchi

An object of the present invention is to provide an injection solution for boron neutron capture therapy. Provided is an injection solution for boron neutron capture therapy, containing p-boronophenylalanine or a pharmaceutically acceptable salt thereof, with a ratio of boron 10 of boron atoms in a compound of 75% or more; a sugar alcohol; an antioxidant; and water, the injection solution having a pH of 6.5 to 7.8 and an osmotic pressure ratio of 1.0 to 1.8, the injection solution being to be administered by intravenous drip injection.

Injection containing p-boronophenylalanine

A control lever device of an industrial vehicle includes a control lever that is tiltable forward and rearward relative to a vehicle body of the industrial vehicle and that includes a control knob, a switch button that is provided on the control knob and adapted to be pushable while the control lever is operated. The switch button has a movement axis indicating a movable direction of the switch button. The movement axis is inclined forward relative to a direction orthogonal to an extending direction of the control knob so that a pushing direction of the switch button is directed rearward from the direction orthogonal to the extending direction of the control knob.

Control lever device of industrial vehicle

The present invention involves preparing compounds represented by the following formula: from a compound of the following formula:  In these formulae: Rrepresents a Br group, an iodine group, a Cl group, an NOgroup, or an NHgroup; Rrepresents a halogen group, an NOgroup, an NHgroup, Sn(R), N&#x2550;N&#x2014;NRR, OSOR, N RR, phenyliodonium, a heterocyclic group iodine, boric acid, or a borate ester; Rrepresents a protective group PG; Ror Rrepresent hydrogen, a protective group PG, or CH(CH)C&#x2550;N, in which NRRare together.

Production method for 2-fluoro-4-borono-L-phenylalanine, and precursor of 2-fluoro-4-borono-L-phenylalanine

The present invention involves preparing compounds represented by the formula. (In the formula: Rrepresents a Br group, an iodine group, a Cl group, an NOgroup, or an NHgroup; Rrepresents a halogen group, an NOgroup, an NHgroup, Sn(R), N&#x2550;N&#x2014;NRR, OSOR, NRR, phenyliodonium, a heterocyclic group iodine, boric acid, or a borate ester; Rrepresents a protective group PG; Ror Rrepresent hydrogen, a protective group PG, or CH(CH)C&#x2550;N, wherein NRRare together.)

F-labeled 4-boronophenylalanine (BPA) can be produced by preparing and further processing a precursor ofF-labeled BPA represented by the following formula: in which Rrepresents a bromo group, an iodo group, a fluoro group, a diazaborinane derivative, BX3or BX3M(wherein X represents a halogen atom; and Mrepresents a monovalent monoatomic cation, a polyatomic cation or a complex cation).

Method for producing 4-borono-L-phenylalanine having 18F atom introduced thereinto, and precursor of 4-borono-L-phenylalanine having 18F atom introduced thereinto

Provided are: a novel chiral 4-boronophenylalanine (BPA) derivative; a method for producing the derivative; and a method for producingF-2-fluoro-4-borono-L-phenylalanine (F-labeled BPA; 18F-BPA) using the derivative. A compound represented by formula (1) is prepared. In the formula, R represents BRR, BXor BXM(wherein X represents a halogen atom, and Mrepresents a monovalent monoatomic cation, a polyatomic cation or a complex cation); Rrepresents a hydrogen atom or a protecting group PG1; Rrepresents a hydrogen atom or a protecting group PG2; Rand Rindependently represent OH, or R, Rand B together form a ring that serves as a protecting group; and Y represents a halogen atom, NO, NH, Sn(R), N&#x2550;N&#x2014;NRR, OSOR, NRR, a substituted or unsubstituted phenyliodo group or a substituted or unsubstituted heterocyclic iodo group. The compound is reacted with a fluorination reagent to prepareF-labeled BPA.

[object Object]

To provide a technique for simply and easily producing a high-purity difluorophosphate and provide a production process of an electrolytic solution using the obtained difluorophosphate, an electrolytic solution and a secondary battery. A process for producing a difluorophosphate, comprising the following step (1) or (2): Also, a nonaqueous electrolytic solution containing the obtained difluorophosphate, and a nonaqueous electrolytic secondary battery containing the nonaqueous electrolytic solution.

Production process of difluorophosphate, nonaqueous electrolytic solution and nonaqueous electrolytic secondary battery

A fine treatment agent according to the present invention is a fine treatment agent for the fine treatment of a multilayer film, including a tungsten film and a silicon oxide film comprising at least one from among hydrogen fluoride, nitric acid, ammonium fluoride and ammonium chloride. Thus, a fine treatment agent which makes fine treatment on a multilayer film, including a tungsten film and a silicon oxide film, possible by controlling the etching rate and a fine treatment method using the same can be provided.

Fine treatment agent and fine treatment method using same

A vehicle control device controls an automatic transmission by utilizing road information stored in a navigation system unit. In response to the road information stored in a data memory, the upper-limit of a shiftable transmission speed range is determined, thereby allowing shift-change only within the restricted transmission range. The actual down-shift is carried out after confirming a decelerating operation by the driver, such as release of the accelerator pedal, thereby providing favorable transmission control in conformity with the driver's intention.

Transmission control device responsive to road information

An apparatus for controlling an automatic transmission of an automobile and a method therefor utilize a route guidance system. The apparatus includes a memory which stores road information, a detector for detecting a specific position which is located on a planned driving route from the road information stored in the memory; a position detector for detecting the present position of the automobile; a speed detector for detecting the speed V of the automobile; a sensor for detecting an opening degree .theta. of a throttle of the automobile; a computer for computing a distance 'd' between the detected automobile position and the detected specific position; a driving operation detector for detecting an operation by the driver of the automobile; a first gear ratio selecting device for selecting a first gear ratio for the automatic transmission based on the detected speed V and the detected throttle opening degree .theta.; and a second gear ratio selecting device for selecting a second gear ratio based on the detected speed V, the distance 'd', the detected operation by the driver and the first gear ratio selected by the first gear ratio selecting device. As a result, it is possible to carry out gear change control taking anticipated changes in the driving conditions into account, thus enabling smooth and comfortable driving. Further, since the driver of the automobile can have advance voice notice of control operations, it is possible to avoid confusion caused by sudden unexpected changes.

Apparatus for controlling an automatic transmission of an automobile and

A vehicle, which is either an electric vehicle or a hybrid vehicle, capable of achieving low-pollution emissions and saving energy by maximizing use of the capacity of the battery. A navigation ECU receives input identifying a starting location where the battery is charged, a stopover location, and a destination where battery recharging is planned, and calculates travel distances from the starting location to the stopover location and to the destination based on geographic data for the starting location, the stopover location and the destination, and schedules electric power consumption corresponding to distance travelled, based on the respective calculated distances, to assign a battery residual capacity usage value for each leg of the trip. A vehicle ECU supplies electric power from the battery to the motor in accordance with that schedule.

Vehicle

A hybrid vehicle has an engine and a generator/motor connected through a planetary gear unit to an output shaft and the output of the engine is distributed between the generator and the output shaft. The vehicle is smoothly started by a driving motor. When vehicle speed V reaches an engine starting speed V*, the speed of generator/motor is changed to cause the engine to rotate, the engine is ignited and driving continues with the output torque produced by the engine supplemented by the driving motor. The hybrid vehicle allows for a smooth start and improved driving comfort even if an engine interruption scheme for halting the engine is employed, for example, halting the vehicle while waiting for a traffic signal to change.

Hybrid vehicle

Growing community of inventors

Osaka, Japan

Hideki Nakashima