Hitachi, Ltd.

Shin-kobe Electric Machinery Co., Ltd.

The Furukawa Electric Co., Ltd.

Daiichi Sankyo Company, Limited

Hitachi Automotive Systems, Ltd.

Other

Hitachi Astemo Ltd.

Hitachi Haramachi Semi-conductor, Ltd.

Nippon Telegraph and Telephone Corporation

Hitachi Industrial Equipment Systems Co., Ltd.

Hideki Miyazaki

Akihiko Emori

Kinya Nakatsu

Takuya Kinoshita

Akihiko Kudo

Takeshi Masuda

Hiroyuki Naito

Masao Yoshida

Yuji Kasuya

Takashi Nakada

Yuki Abe

Shinji Ashida

Tsuyoshi Kai

Yusuke Ogitani

Kenichi Onda

Ryuichi Saito

Koji Morita

Mutsuhiro Mori

Toshiya Satoh

Takeshi Tokuyama

Keisuke Horiuchi

Toshisada Mitsui

Yasuo Matsuda

Hiroyuki Shoji

Katsuhiro Hoshino

Satoru Kaneko

Akihiko Kanouda

Katsunori Suzuki

Toshiyuki Ajima

Katsumi Ishikawa

Junichi Sakano

Masato Shiino

Masato Suzuki

Masahiro Nagasu

Katsuki Suematsu

Eiichi Toyota

Motomi Shimada

Koichi Suda

Masahiro Iwamura

Shiho Izumi

Koji Tateno

Yasuyuki Kojima

Shigeyuki Yoshihara

Shin Kimura

Masao Shinoda

Masataka Sasaki

Shinichi Matsumoto

Ichiro Hayakawa

Kenji Kawabata

Kouzou Watanabe

Hiroshi Kimura

Hiroshi Hozoji

Toshiaki Ishii

Yoshitaka Takezawa

Tatsuyuki Yamamoto

Kozo Watanabe

Norikazu Tokunaga

Naoki Sakurai

Takayoshi Nakamura

Kimihisa Furukawa

Mitsuyuki Hombu

Kazuyoshi Sasazawa

Hideo Kobayashi

Jun Yamakawa

Kazuto Oyama

Koji Seo

Kenta Katsuhama

Hiroyuki Yamada

Ryoso Masaki

Kazuo Kato

Yoshitaka Iwaji

Toshiyuki Innami

Osamu Koizumi

Yutaka Takaku

Kazuo Tahara

Tsunehiro Endo

Keiichi Mashino

Kazuji Yamada

Hiroyuki Saito

Noboru Akiyama

Yutaka Suzuki

Kenji Kubo

Satoshi Ibori

Shinji Nagasawa

Tokihito Suwa

Yoshitaka Sugawara

Kiyoshi Sakamoto

Katsunori Nishimura

Akihiro Namba

Masahiko Amano

Minehiro Nemoto

Yukio Kawabata

Tomoyuki Tanaka

Hidefumi Shirahama

Yuhachi Takakura

Satoru Funaki

Satoru Inarida

Keiji Maekawa

Masaaki Takahashi

Ikuo Yamato

As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L-L-L-NH—(CH)n-L-L-L- wherein the antibody is connected to the terminal of L, and the antitumor compound is connected to the terminal of Lwith the nitrogen atom of the amino group at position 1 as a connecting position.

Antibody-drug conjugate

An object of the present invention is to provide a wheel drive device capable of suppressing a temperature increase in an electric motor and a power conversion device and suppressing occurrence of a failure of an electric component. Provided are: an electric motor having a statorand a rotor; a stator holderthat holds the stator; a power conversion devicethat converts power supplied to the electric motor; and a wheel which accommodates the electric motor, the stator holder, and the power conversion deviceon the inner peripheral side. The stator holderincludes a flow paththrough which a cooling medium flows. The flow pathis arranged between the statorand the power conversion device

Wheel drive device and electric vehicle provided with the same

As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the following formula: -L-L-L-NH&#x2014;(CH)n-L-(CH)n-C(&#x2550;O)&#x2014; wherein the anti-HER2 antibody is connected to the terminal L, and the antitumor compound is connected to the carbonyl group of the &#x2014;(CH)n-C(&#x2550;O)&#x2014; moiety with the nitrogen atom of the amino group at position 1 as the connecting position

Method for treating cancer comprising administration of anti-HER2 antibody-drug conjugate

As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L-L-L-NH&#x2014;(CH)n-L-L-L- wherein the antibody is connected to the terminal of L, and the antitumor compound is connected to the terminal of Lwith the nitrogen atom of the amino group at position 1 as a connecting position.

As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the following formula: -L-L-L-NH&#x2014;(CH)n-L-(CH)n-C(&#x2550;O)&#x2014; wherein the anti-HER2 antibody is connected to the terminal L, and the antitumor compound is connected to the carbonyl group of the &#x2014;(CH)n-C(&#x2550;O)&#x2014; moiety with the nitrogen atom of the amino group at position 1 as the connecting position. 

Method of treating cancer comprising administration of anti-HER2 antibody-drug conjugate

A motor can be controlled in a user-friendly manner so that a phase current based on an input command torque command value is caused to flow to at least one among U-phase, V-phase, and W-phase windings of the motor, so that a predetermined in-phase current is superimposed on the phase current and caused to flow to at least one among the windings. The motor is controlled such that energization to one winding corresponding to a predetermined energization stop phase is stopped, for example, so that energization to the U-phase winding is stopped, and so that a V-phase current, a W-phase current and an in-phase current are caused to flow to each winding corresponding to a phase other than the energization stop phase, for example, so that the V-phase current, the W-phase current and the in-phase current are caused to flow to the V-phase winding and the W-phase winding.

Motor control device and electric vehicle

As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the formula: L-L-L-NH&#x2014;(CH)n-L-L-Lor -L-L-L- wherein the anti-HER2 antibody is connected to the terminal L, and the antitumor compound is connected to the terminal Lor Lwith the nitrogen atom of the amino group at position 1 as the connecting position. 

(Anti-HER2 antibody)-drug conjugate

Pulsating current (ripple) is generated in a zero-phase current to increase a loss. A motor control system includes an inverter which drives a motor which includes windings separately wound around each phase and an inverter control unit which generates an output voltage pulse corresponding to each phase to control the inverter on the basis of a torque command value and a rotor position of the motor. The inverter control unit divides the output voltage pulse of at least one phase of the output voltage pulses into several pulses during one period of the output voltage pulse such that a zero-phase voltage of only one of positive and negative polarities is output several times from the motor in the one pulse period.

Motor control system and electric vehicle

An electric power conversion apparatus includes a channel case in which a cooling water channel is formed; a double side cooling semiconductor module that has an upper and lower arms series circuit of an inverter circuit; a capacitor module; a direct current connector; and an alternate current connector. The semiconductor module includes first and second heat dissipation metals whose outer surfaces are heat dissipation surfaces, the upper and lower arms series circuit is disposed tightly between the first heat dissipation metal and the second heat dissipation metal, and the semiconductor module further includes a direct current positive terminal, a direct current negative terminal, and an alternate current terminal which protrude to outside. The channel case is provided with the cooling water channel which extends from a cooling water inlet to a cooling water outlet, and a first opening which opens into the cooling water channel.

Electric power conversion apparatus

A six-wire three-phase motor that can realize both of increasing an output and reducing a torque ripple is provided. A six-wire three-phase motor is a six-wire three-phase motor including: a stator including a winding wire wound independently between phases; and a rotor including a plurality of magnets in a circumferential direction, wherein the stator or the rotor is configured in such a manner that a third harmonic current component in a motor current of when an overmodulation voltage based on a PWM signal is applied becomes higher than a third harmonic current component in a motor current of when a sinusoidal modulation voltage based on the PWM signal is applied.

Six-wire three-phase motor, inverter device, and motor system

As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula (I) is conjugated to an antibody via a linker having a structure represented by the following formula: -L-L-L-NH&#x2014;(CH)n-L-L-L- or -L-L-L- wherein the antibody is connected to the terminal of L, the antitumor compound is connected to the terminal of Lor L, and any one or two or more of linkers of L, L, and Lhas a hydrophilic structure.

Antibody-drug conjugate produced by binding through linker having hydrophilic structure

In a case where a switching element of an inverter does not operate properly due to failure or the like, a three-phase short circuit cannot be made, and an induced voltage cannot be suppressed. An induced voltage suppression device is electrically connected to the three-phase wiring between the power converter and the motor, in parallel to the power converter. A rectification circuit including a three-phase diode bridge circuit. A DC voltage source including a capacitor. A voltage detection circuit detects a voltage of both ends of the DC voltage source. In a short circuit, when a transistor of the voltage detection circuit is turned on, transistors are turned on to perform three-phase short-circuit operation to suppress an induced voltage of the motor. Since the induced voltage suppression device secures a DC voltage by the induced voltage of the motor as a drive source in a self-excited manner, it is possible to suppress the induced voltage even when an abnormality occurs in the power converter.

Induced voltage suppression device, motor system, and power conversion system

Provided is a motor drive device capable of adjusting a 0-axis current to a desired value. A motor drive device (inverter device) for an open winding type motorin which a stator winding wire includes three-phase independent winding wires, andincludes a plurality of single-phase inverters, andprovided for each of the winding wirestoto individually apply a voltage to a corresponding winding wire, and a controllerthat controls each of the single-phase invertersto. The controlleradjusts a 0-axis current to a predetermined value by alternately and repeatedly generating a first period in which a sum of voltages applied to the respective independent winding wirestois set to a value other than zero to offset the 0-axis current and a second period in which the sum of the voltages applied to the respective winding wirestois set to zero.

Motor drive device

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Hitachi, Japan

Hideki Miyazaki