Santen Pharmaceutical Co., Ltd.

Sanyo Electric Co., Ltd.

Hideki Miyake

Tomoko Oda

Masami Makino

Daisuke Shii

A method for changing a condition of an eyelid of a hairless animal, a model animal for evaluating a therapeutic or prophylactic effect against an eyelid disease obtained by the method, a method for producing the model animal, a method of screening using the model animal and a substance having a therapeutic or prophylactic effect against an eyelid disease selected by the method of screening, and a therapeutic or prophylactic agent against an eyelid disease containing the substance as an active ingredient.

Method for changing condition of eyelid of hairless animal

A method for suppressing obstruction of meibomian gland in a mammalian subject, the method comprising administering to the mammalian subject an eye drop comprising 0.01 to 0.5% (w/v) of sirolimus or a pharmaceutically acceptable salt thereof as a sole active ingredient, wherein the eye drop is administered to an eye of the mammalian subject 1 to 2 times per day.

Therapeutic agent for meibomian dysfunction

A method for changing a condition of an eyelid of a mammal excluding a human, a model animal for evaluating a therapeutic or prophylactic effect against an eyelid disease obtained by the method, a method for producing the model animal, a method of screening using the model animal and a substance having a therapeutic or prophylactic effect against an eyelid disease selected by the method of screening, and a therapeutic or prophylactic agent against an eyelid disease containing the substance as an active ingredient.

Method for changing condition of an eyelid for evaluation of an eyelid disease involving plugging of meibomian gland orifices and/or telangiectasia by administration of complete freund's adjuvant

An electronic device including a vibration generator having an eccentric weight member attached to the output of a motor. The motor is accommodated into a bracket made from elastic material, and the bracket is held in a casing. The bracket has a prism-shaped body, and has a through hole in which the motor is tightly fitted formed the central portion of the body, and the peripheral wall defining the through hole is formed with a slit cut from one end face of the body to a central portion of the body in a specified depth. Accordingly, the vibration generator is accommodated into the bracket with great ease. Moreover, the motor of the vibration generator is unlikely to change easily its rotating angle posture in the interior of the bracket while the bracket is assembled into a casing.

Electronic device incorporating vibration generator

A portable electronic device comprises a casing a first circuit board provided in the interior of the casing and a circuit module attached to the first circuit board The circuit module comprises a chassis engaged with the first circuit board and a second circuit board fixed to the chassis A male connector attached to one circuit board and a female connector attached to the other circuit board are engaged with each other to have the both circuit boards electrically connected. The chassis is formed with a pair of arms holding and supporting the respective end faces of the first circuit board on respective end portions of the chassis The pair of arms extends to the first circuit board on respective end portions of the chassis and an end portion of each arm is held between an end face of the first circuit board and the inner face of the casing This prevents a male connector and a female connector from being impaired resulting from impulsive force exerted.

Growing community of inventors

Ikoma, Japan

Hideki Miyake