Daiichi Seiyaku Co., Ltd.

Meito Sangyo Co., Ltd.

Hideki Miyaji

Hiroshi Kikuchi

Sadao Hirota

Shusaburo Hokukoku

Munehiro Tomikawa

Novel mannobiose derivative represented by the general formula [I]: ##STR1## wherein groups of R.sub.1 to R.sub.5 each represents --OH, --OR.sub.6, --NHR.sub.6, (R.sub.6 represents an acyl group) or a group represented by the following formula (a), (b), (c), (d) or (e), provided that one of R.sub.1 to R.sub.5 represents --OR.sub.6 or --NHR.sub.6, one of the other 4 groups of R.sub.1 to R.sub.5 represents one of the groups represented by the formulae (a) to (e), and the remaining 3 groups of R.sub.1 to R.sub.5 represent --OH: ##STR2## wherein   represents .alpha. or .beta. bond are provided by the invention. These compounds give liposomes a specific affinity for Kupffer cells of liver, and can be produced industrially.

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Inazawa, Japan

Hideki Miyaji