Kuraray Co., Ltd.

Hideki Matsuda

Manzo Shiono

Goro Asanuma

Shigeki Kikuyama

Takanobu Shin

Takashi Fukumoto

Osamu Nakayama

Fumihiko Okabe

Jyunko Sato

Takashi Yamaguchi

Toshiki Endo

There is provided a means to produce industrially a highly pure 2-hydroxy-4-oxa-5-thiatricyclo[4.2.1.0]nonane 5,5-dioxide derivative in high yield from highly pure and industrially available raw materials. The production method for a sultone derivative of the present invention comprises a step (A) to obtain a sulfonic acid derivative by hydrolyzing a sulfonyl halide derivative represented by the following chemical formula 1: or an enantiomer thereof and a step (B) to obtain a corresponding sultone derivative represented by the following chemical formula 2: or an enantiomer thereof by treating the sulfonic acid derivative with a oxidizing agent.

Production method for sultone derivatives

A process by which an &#x3b1;-oxocarbonyl compound useful as an intermediate for pharmaceuticals/agricultural chemicals can be industrially advantageously and efficiently produced in a high yield. The process, which is for producing an &#x3b1;-oxocarbonyl compound represented by the general formula (I) wherein Rand Rare as defined in the description, comprises oxidizing an &#x3b1;-hydroxycarbonyl compound represented by the general formula (II) with oxygen or air in the presence of a carboxylic acid and at least one vanadium compound selected from divanadium pentaoxide, divanadium trioxide, divanadium tetraoxide, ammonium metavanadate, sodium metavanadate, potassium metavanadate, triethoxyoxovanadium, tripropoxyoxovanadium, triisopropoxyoxovanadium, vanadium oxobis(acetylacetonate) and vanadium tris(acetylacetonate).

Process for producing alphaoxocarbonyl compound

Method for producing pyridine derivatives

A pyridine alcohol derivative represented by General Formula III

Process for the preparation of 2-chloro-5-chloromethyl-1,3-thiazole

A pyridine alcohol derivative represented by General Formula III ##STR1## (where A represents a divalent organic group which may contain one to three oxygen atoms, nitrogen atoms and/or sulfur atoms, wherein A may form a 5-, 6-, 7-, or 8-membered ring together with two bonded carbon atoms, where said ring may form a condensed ring with one or more additional rings; R.sup.5 represents a hydrogen atom, --CHR.sup.1 R.sup.2, or an alkenyl group, an aryl group or an aralkyl group which may be substituted; R.sup.1 and R.sup.2 each independently represent a hydrogen atom or a hydrocarbon group which may be substituted; and R.sup.6 represents a hydrogen atom, an alkyl group, an alkenyl group, an aryl group or an aralkyl group which may be substituted), is produced by:

Intermediates for producing pyridine derivatives

According to the present invention, provided are

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Niigata, Japan

Hideki Matsuda