Otsuka Pharmaceutical Company, Limited

Hideki Kitagaki

Hidetaka Hiyama

Junpei Haruta

Nobuaki Ito

Minoru Okada

Kunio Oshima

Isao Takemura

Takumi Sumida

Masatoshi Chihiro

Masaya Kato

Tetsuyuki Uno

Norifumi Sato

Hironobu Ishiyama

Kenji Watanabe

Yoko Sakamoto

Tomonori Shibata

Hideki Kawasome

Kazuhiko Fujita

The present invention provides a oxazole compound represented by Formula (1), or a salt thereof: wherein Ris an aryl group which may have one or more substituents; Ris an aryl group or a nitrogen atom-containing heterocyclic group each of which may have one or more substituents; and W is a divalent group represented by &#x2014;Y-A- or or &#x2014;Y&#x2014;C(&#x2550;O)&#x2014; wherein Yis a group such as &#x2014;C(&#x2550;O)&#x2014;, Ais a group such as a lower alkylene group, and Yis a group such as a piperazinediyl group. The oxazole compound has a specific inhibitory action against phosphodiesterase 4.

Oxazole compound and pharmaceutical composition

The present invention provides a oxazole compound represented by Formula (1), or a salt thereof: wherein Ris an aryl group which may have one or more substituents; Ris an aryl group or a nitrogen atom-containing heterocyclic group each of which may have one or more substituents; and W is a divalent group represented by &#x2014;Y-A- or &#x2014;Y&#x2014;C(&#x2550;O)&#x2014; wherein Yis a group such as &#x2014;C(&#x2550;O)&#x2014;, Ais a group such as a lower alkylene group, and Yis a group such as a piperazinediyl group. The oxazole compound has a specific inhibitory action against phosphodiesterase 4.

Thiazole compounds for inhibiting the activity of phosphodiesterase 4, the production of tumor necrosis factor alpha, and the production of interleukin 4. The compounds of the invention are represented by general formula (1): 

Thiazole compounds and their use for inhibiting phosphodiesterase 4, TNF-&#x3b1;, and IL-4

Thiazole compounds for inhibiting the activity of phosphodiesterase 4, the production of tumor necrosis factor alpha, and the production of interleukin 4. The compounds of the invention are represented by general formula (1): wherein A is any one of the following groups (i) and (ii): (i) &#x2014;CO&#x2014;B&#x2014; wherein B is a Calkylene group and (ii) &#x2014;CO&#x2014;Ba&#x2014; wherein Ba is a Calkenylene group, and include optical isomers and salts of the compounds.

Thiazole compound and use thereof

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Ako, Japan

Hideki Kitagaki