Otsuka Pharmaceutical Company, Limited

Hideki Kawasome

Nobuaki Ito

Kunio Oshima

Masatoshi Chihiro

Isao Takemura

Takumi Sumida

Hironobu Ishiyama

Hideki Kitagaki

Junpei Haruta

Hidetaka Hiyama

Yoko Sakamoto

Kenji Watanabe

Kazuhiko Fujita

Thiazole compounds for inhibiting the activity of phosphodiesterase 4, the production of tumor necrosis factor alpha, and the production of interleukin 4. The compounds of the invention are represented by general formula (1): 

Thiazole compounds and their use for inhibiting phosphodiesterase 4, TNF-&#x3b1;, and IL-4

Thiazole compounds for inhibiting the activity of phosphodiesterase 4, the production of tumor necrosis factor alpha, and the production of interleukin 4. The compounds of the invention are represented by general formula (1): wherein A is any one of the following groups (i) and (ii): (i) &#x2014;CO&#x2014;B&#x2014; wherein B is a Calkylene group and (ii) &#x2014;CO&#x2014;Ba&#x2014; wherein Ba is a Calkenylene group, and include optical isomers and salts of the compounds.

Thiazole compound and use thereof

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Naruto, Japan

Hideki Kawasome