Konica Corporation

Konica Minolta, Inc.

Konica Minolta Medical and Graphic, Inc.

Konica-minolta Holdings, Inc.

Tohoku University

Hideki Hoshino

Hisatake Okada

Naoko Furusawa

Satoshi Ito

Kohsuke Gonda

Noriaki Ohuchi

Kensaku Takanashi

Yasushi Nakano

Mika Watanabe

Hideki Gouda

Kazuya Tsukada

Keizou Takano

Masaru Takahashi

Shinichi Suzuki

Tetsuya Yamamoto

Hidenobu Ohya

Masaki Nakamura

Kiyokazu Morita

Kazuyoshi Goan

Yasushi Nagata

Hideki Takiguchi

Masayuki Ushiku

Shu Nishiwaki

Takuji Aimiya

Motohiro Takeda

Hitoshi Adachi

Naoto Niizuma

Takenori Omata

Ryo Aoyama

Masayoshi Yamauchi

Kazuho Urayama

Keizu Takano

A pattern forming method capable of easily removing a discontinuous portion in a pattern while keeping resistance of the pattern low. A pattern forming method including at least a printing step of printing a pattern intermediate containing a conductive material on a base material, and a plating step of subjecting the pattern intermediate to an electroplating treatment, in which the pattern intermediate printed in the printing step has a plating target portion that is energized in the plating step and a discontinuous portion that is discontinuously formed from the plating target portion and is not energized in the plating step, and in the plating step, by performing an electric field plating treatment using a plating solution containing at least two or more types of metal salts containing different types of metals and a complexing agent, the discontinuous portion of the pattern intermediate is removed to form a pattern constituted by the plating target portion covered with a plating film.

Pattern forming method

The present invention provides a staining method in which the fluorescent staining properties in a fluorescently-immunostained specimen are not reduced even when an oil-based mounting medium is used. The present invention also provides a method of preventing deterioration of a fluorescent label caused by irradiation with excitation light and improving the light resistance in a fluorescently-immunostained specimen obtained by the staining method. The biological substance detection method according to the present invention is a biological substance detection method for specifically detecting a biological substance from a pathological specimen, which includes the steps of: immunostaining the specimen with a fluorescent label; immobilizing the thus stained specimen; and mounting the thus immobilized specimen using a mounting medium including an organic solvent not freely miscible with water. In the biological substance detection method, the above-described mounting medium further includes a discoloration inhibitor.

Method for detecting biological material

Provided is a method for staining a tissue enabling highly precise staining, by which the expression amount and/or the location of a biological substance in a tissue sample can be detected with a high quantitativity together with detailed information that can be obtained by bright field observation. The tissue staining method of the present invention is a method for staining a tissue, in which both staining that allows bright field observation and fluorescence staining are carried out for the same specific biological substance.

Method for staining tissue

A detection method for a specific biological substance uses, as a color former, fluorescent substance-encapsulated nanoparticles which have biological substance-recognizing molecules. The biological substance-recognizing molecules specifically recognize a specific biological substance. The biological substance-recognizing molecules are bonded to the surface of the nanoparticles. Nanoparticles encapsulating no fluorescent substance are used as a blocking agent for preventing the fluorescent substance-encapsulated nanoparticles from being non-specifically adsorbed on a biological substance other than the specific biological substance.

Detection method for biological substance

A semiconductor nanoparticle assembly including semiconductor nanoparticles having a core/shell structure, and wherein the semiconductor nanoparticles are bonded by means of amide bonds.

Semiconductor nanoparticle assembly

Disclosed are fluorescent substance-containing silica nanoparticles containing a fluorescent substance therein featured in that the surface of the silica nanoparticles is coated with a material having a bulk refractive index of from 1.60 to 4.00. The invention can provide fluorescent substance-containing silica nanoparticles excellent in long term storage stability and a biosubstance labeling agent employing the same.

Fluorescent substance-containing silica nanoparticles with coating having high bulk refractive index

Disclosed is a fluorescent semiconductor microparticle assembly comprising at least three kinds of fluorescent semiconductor microparticles with an average particle size of from 1 to 10 nm, having the same chemical composition, a different average particle size and a different emission maximum wavelength in the emission spectra, wherein a standard deviation of emission intensity in each of the at least three kinds of fluorescent semiconductor microparticles is not more than 15%.

Fluorescent semiconductor microparticle assembly, fluorescent labeling agent assembly for biological substance, and bioimaging method and biological substance analysis method using the assemblies

A production method of nano-sized silicon crystal particles comprising the step of allowing monosilane to be oxidized in a bulk liquid phase to form the nano-sized silicon crystal particles within the bulk liquid phase, wherein a liquid of the bulk liquid phase is an unsaturated hydrocarbon free from an oxidizing gas; and isolating the nano-sized silicon crystal particles from the bulk liquid phase.

Production method of nanoparticle

Disclosed are a phosphor in which prevention of aging deterioration of luminance and prevention of deterioration of discharging characteristics are compatible, a method of manufacturing the phosphor, and a plasma display panel manufactured by using the phosphor. A phosphor of the invention containing Mn as an activator is one with Mn serving as a major emission, wherein a ratio of an activator concentration in a superficial portion of a phosphor particle to an activator concentration inside the phosphor particle is 0.3-0.7.

Phosphor and plasma display panel

A manganese activated zinc silicate phosphor comprising phosphor particles having a crystal lattice distortion factor of 0.01 to 1.0% which exhibits high emission intensity and reduced afterglow time and a PDP utilizing the same which exhibits high white luminance and a high luminance maintaining ratio.

Manganese activated zinc silicate phosphor and plasma display panel

A green light emitting silicate-containing phosphor having both enhanced luminescence intensity and a shortened persistence time and a method for manufacturing the foregoing phosphor can be provided, and a phosphor precursor can also be manufactured by releasing a mixed solution from an exit of the outlet flow passage, after a suspension containing a silicon compound is supplied into the first inlet flow passage, a solution containing a metallic compound for forming a silicate-containing phosphor precursor is supplied into the second inlet flow passage, and the foregoing suspension and solution are introduced into the contact section so as to mix with each other with controlling a flow of the mixed solution so as to keep a Reynolds number of the mixed solution to be 3&#xd7;10to 1&#xd7;10.

Manufacturing method of silicate-containing phosphor and silicate-containing phosphor precursor

A phosphor includes particles having an average particle size of from 10 nm to 2 &#x3bc;m, wherein 90% by mass or more of all of the particles have particle sizes within &#xb1;30% of the average particle size and a ratio of particles having no corners to all of the particles is 80% or more in number.

Phosphor

A precursor of a silicate phosphor is formed by mixing a silicon system liquid material, in which a silicon system material is dispersed in a liquid, with a metal system liquid material including a metallic element, and the silicate phosphor is obtained by calcining the obtained precursor.

Phosphor, method for producing phosphor and its precursor, and display device

At least one kind of a rear earth element or an alkaline earth metal element is activated together with manganese in a zinc silicate system phosphor, and a mean particle size of the phosphor is between 0.01 and 1.0 &#x3bc;m.

Growing community of inventors

Tokyo, Japan

Hideki Hoshino