Takeda Pharmaceutical Company Limited

Sony Corporation

Hideki Hirose

Tohru Yamashita

Takeshi Yamasaki

Shizuo Kasai

Zenichi Ikeda

Asato Kina

Ryo Mizojiri

Sachie Morimoto

Koji Watanabe

Tsuneo Yasuma

Ikuo Fujimori

Shuji Kitamura

Yoichi Nishikawa

Takafumi Yukawa

Minoru Ikoma

Takuya Fujimoto

Makoto Kamata

Taiji Asami

Nobuyuki Takakura

Katsunori Sato

Masataka Murakami

Masaki Ogino

Naoki Nishizawa

Kenjiro Sato

Tomoya Yukawa

Nobuyuki Matsunaga

Jun Ueshima

Kazuko Yonemori

Kyoko Toyofuku

Yoshiyuki Takayanagi

Takashi Nakahata

The present invention provides a compound or a salt thereof having a calcium-sensing receptor antagonistic activity, and being expected to be useful as an agent for preventing or treating heart failure, pulmonary hypertension, or the like. The compounds represented by formula (I) or a salt thereof has a calcium-sensing receptor antagonistic activity, and is expected to be useful as an agent for preventing or treating heart failure, pulmonary hypertension, or the like, wherein each symbol is as described in the specification.

Heterocyclic compounds having a calcium-sensing receptor antagonistic activity

Heterocyclic compound

A compound having an SSTR5 antagonist action and use of the compound as a medicament are provided. Specifically, a compound represented by the following formula: 

Tetrahydronaphthyridine somatostatin receptor 5 antagonists

Provided is a compound represented by the following formula (1) or a salt thereof, which has an SSTR5 antagonistic action: wherein each symbol has the same definition as in the specification. 

Spiro azetidine isoxazole derivatives and their use as SSTR antagonists

A compound having an SSTR5 antagonist action and use of the compound as a medicament are provided. Specifically, a compound represented by the following formula: wherein each symbol is as defined herein, or a salt thereof, a medicament comprising the compound or a salt thereof, and use of the compound or a salt thereof as an agent for the prophylaxis or treatment of diabetes mellitus are provided.

The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Bicyclic compound

A compound having an SSTR5 antagonist action and use of the compound as a medicament are provided. Specifically, a compound represented by the following formula: wherein each symbol is as defined herein,or a salt thereof, a medicament comprising the compound or a salt thereof, and use of the compound or a salt thereof as an agent the prophylaxis or treatment of diabetes mellitus are provided.

The present invention provides to a compound having an ACC inhibitory action, which is useful as an agent for the prophylaxis or treatment of obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia, cancer and the like, and has superior efficacy. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification.

An active filter apparatus makes it possible for a filter adjusting circuit to require a small number of elements when the filter adjusting circuit is contained in an integrated circuit, to be not easily affected by variations in the characteristics of the elements which form the circuit, and to be capable of easily adjusting the frequency characteristics of the filter to be adjusted. A characteristics conversion device converts, on the basis of an input signal and an output signal of the filter, to a characteristics conversion signal whose amplitude when the adjustment is completed is considerably larger than that of the output signal. As a result, the amplification factor of the characteristics conversion device, necessary to detect a maximum or minimum value of a characteristics conversion signal, is considerably small. Therefore, it is possible to considerably decrease an offset error of the characteristics conversion device.

Active filter circuit apparatus

Growing community of inventors

Kanagawa, Japan

Hideki Hirose