Hitachi-high-technologies Corporation

Hitachi, Ltd.

Hitachi High-tech Corporation

Tdk Corporation

Meinan Machinery Works, Inc.

Hoya Corporation

Osaka University

Kagoshima University

Tokyo Metropolitan Institute of Medical Science

Ehime University

Japan As Represented by Director-general of National Institute of Infectious Diseases

Nippi Corporation

Toko Yakuhin Kogyo Kabushiki Kaisha

Japan As Represented by the Director-general of National Institute of Infectious Diseases

Tokyo Yakuhin Kogyo Co., Ltd.

Hideki Hasegawa

Yuichiro Hashimoto

Masuyuki Sugiyama

Hiroyuki Satake

Izumi Waki

Masao Suga

Takashi Baba

Hidetoshi Morokuma

Masuyoshi Yamada

Yasuaki Takada

Kazushige Nishimura

Shun Kumano

Masako Ishimaru

Takashi Miyazaki

Taizou Kamishita

Shuhei Hashiba

Mikio Tsutsui

Takayuki Yamauchi

Nobumi Harada

Sekiji Takahashi

Satoshi Suga

Shinji Saito

Hideki Kambara

Masao Kamahori

Hisashi Nagano

Tomoyuki Sakai

Ken Ninomiya

Hiroyuki Yasuda

Tomonori Ueno

Michinori Kohara

Takashi Irie

Kenichi Shinde

Masashi Iwata

Akihiko Okumura

Kyoko Kohara

Yuki Taga

Sadao Manabe

Katsuaki Uchida

Kiyoko Goto

Yukiko Hirabayashi

Takahiro Sanada

Yoichi Hiasa

Osamu Yoshida

Yuki Nagaya

Takeshi Tanimoto

Tadaki Suzuki

Hiroshi Tadano

Hiroshi Tadanoh

Akira Ainai

Masayuki Sugiyama

Tetsuhisa Nakamura

Tomohiro Ogawa

Satake Hiroyuki

There are provided an ion source that can accurately and efficiently grasp whether a tip end position on a capillary downstream side is proper and a control method therefor. An ion source according to an embodiment of the present invention measures an electric current generated due to the application of a voltage to a capillary by a power supply when a sample is not introduced into the capillary. When the electric current is within tolerance, the ion source outputs projection amount information expressing that the projection amount of the capillary is proper, and the ion source outputs the projection amount information expressing that the projection amount is improper when the projection amount is not within the tolerance.

Ion source, mass spectrometer, ion source control method

A mass spectrometer includes an ion source, an ion guide, a quadrupole mass filter, a detector, DC and RF power sources, and a voltage control device for controlling an acceleration voltage by controlling the power source. The voltage controller controls the acceleration voltage such that it is increased as the mass-to-charge ratio of ions to be measured is increased within a control region. The control region is surrounded, having one coordinate axis representing the mass-to-charge ratio of the ions passing the ion guide and another axis representing the acceleration voltage applied to the ion guide, by a line representing a lower limit of a stable region where the ions pass the ion guide stably, a line representing an ion mobility of the ions, an upper side representing an upper limit of the acceleration voltage, and a lower side representing a value at which the acceleration voltage is zero.

Mass spectrometry device control method, mass spectrometry system, and voltage control device

Provided are an ion source and a mass spectrometer that reduce a dead volume of the connecting part of a pipe to a capillary. An ion source has a capillary and a pipe. The capillary has a large-diameter part that forms a capillary upstream-side end face on an upstream side. The large-diameter part has a large-diameter part downstream side face on a downstream side. The pipe has a pipe downstream end face on the downstream side. A capillary retaining unit has a hole through which the capillary downstream-side end face is passable and a face on which the large-diameter part downstream side face is installable. The ion source includes a pipe retaining unit that retains the pipe. The capillary retaining unit and the pipe retaining unit are disposed such that the capillary upstream-side end face contacts the pipe downstream end face to connect the capillary to the pipe.

Ion source and mass spectrometer

A liquid chromatograph mass spectrometer specifying a location where a flow path is clogged and recovering in a short time. The liquid chromatograph mass spectrometer includes a first flow path passing through a separation column, a second flow path not passing through the separation column, a mass spectrometry unit on the downstream side of the first and second flow paths that analyzes a sample that has passed through the first flow path, a first valve for connecting any one of the first and second flow paths to the mass spectrometry unit, and a controller for controlling driving of the first valve connecting the first flow path to the mass spectrometric unit, comparing the measured value of the mass spectrometric unit with a predetermined threshold value, and connecting the second flow path to the mass spectrometry unit when it is determined to be abnormal.

Liquid chromatograph mass spectrometer

An object of the present invention is to improve the safety and stability of an ion source by making a temperature distribution of a heated gas uniform while ensuring heat insulating properties. The ion source according to the present invention includes a gas introduction port inside a probe holder that holds an ion probe. A heater that increases the temperature of a heated gas and the gas introduction port are connected by a plurality of pipes which extend along an extending direction of the ion probe and are independent of each other (see FIG.).

Ion source

The present invention relates to a hepatitis B vaccine composition for spray-administration to nasal mucosa for preventing and treating hepatitis B, which comprises hepatitis B antigen and carboxy vinyl polymer.

Nasal hepatitis B vaccine composition and method for producing same

For increasing a speed of fragmentation of a sample, such as a protein and a peptide, to enhance introduction efficiency into a detector, such as a mass spectrometer, a liquid feeding pump, a sample injector, and a separation columnthat are connected via pipes are included, and further, a heating unitfor heating a pipe between the sample injectorand the separation column, and a pressure regulating unitprovided between the heating unitand the separation columnfor regulating the inner pressure of the pipe heated by the heating unit, are included.

Sample fragmentation device using heating and pressure regulation between sample injector and separation column

Provided are: a polymeric IgA-type recombinant antibody; a medicine containing this polymeric IgA-type recombinant antibody as an active ingredient; a method for producing this polymeric IgA type antibody, the method including the step of coexpressing an IgA-type antibody heavy-chain protein, an antibody light-chain protein, an antibody J-chain protein, and a secretory component protein within a single cell; and a method for improving the antigen-binding activity or neutralizing activity of this antibody, the method including the step of making an antibody into a polymeric IgA-type.

Polymeric IgA-type recombinant antibody and use thereof

A separation column connecting device includes: a column holder for retaining a separation column; a first fitting holder carrying a first fitting which includes a seal portion to be connected to an upstream seal portion of the separation column and connected with an upstream pipe; a second fitting holder carrying a second fitting which includes a seal portion to be connected to a downstream seal portion of the separation column and connected with a downstream pipe; a body member to which either one of the first fitting holder and the second fitting holder is fixed; a driver for moving, relative to the body member, the first fitting holder or the second fitting holder not fixed to the body member; a guide for guiding the column holder in a direction of movement driven by the driver; and an elastic body disposed between the column holder and the second fitting holder.

Separation column connection device, connection method, and analysis system

In order to make an analyzer with an ion mobility separation part have high durability and robustness, the analyzer includes an ion source, an ion mobility separation part which includes a pair of facing electrodes to which a high frequency voltage and a DC voltage are applied, and a shielding electrode which is provided between the ion source and the ion mobility separation part and to which a DC voltage is applied, wherein the shielding electrode includes an ion flow path connecting an inlet from which ions from the ion source are introduced and an outlet from which the ions are discharged thereinside, and the ion flow path is bent so that the outlet is unable to be seen from the inlet.

Analysis device provided with ion mobility separation part

An ion analysis device includes: an ion source that ionizes an analyte in a liquid sample; an ion guide into which droplets and ions produced in the ion source are introduced, the ion guide having different outlets, one outlet being an ion outlet for the ions and the other outlet being a droplet outlet for the droplets; an ion analysis unit that analyzes ions ejected from the ion outlet; a droplet measurement unit that is placed on an axis of the droplet outlet, and measures the amount of droplets; and an analysis control section that compares the amount of droplets measured at the droplet measurement unit with a threshold.

Ion analysis device

In order to implement a high-sensitivity mass spectrometry through an improvement in solvent removal efficiency during electrospray ionization and the like, an ionization device is provided with a light guide pathwhich guides light from a light source to sample microparticles generated by a micronization device to irradiate the microparticles. A closest distance d2 between a spatial areain which the sample microparticles are present and a distal endof the light guide path is greater than or equal to 0.1 mm and less than or equal to 20 mm. A closest distance d1 between an area of light irradiationby the light guide path and any of a sample surface, a micronization device, and a sample holding unit that is the closest is greater than or equal to 0.01 mm and less than or equal to 10 mm.

Ionization device

To reduce contamination of the apparatus with an additive and to quickly switch spraying and stopping of the additive, provided is an ion analyzer including: an ion source for ionizing a measurement target substance, a spray unit for atomizing and spraying toward the measurement target substance a liquid containing an additive that reacts with the measurement target substance; a separation analysis unit for separately analyzing an ion generated by a reaction between the measurement target substance and the additive; a detector for detecting the ion that has been separately analyzed by the separation analysis unit; and a control unit for lowering a flow rate of the additive supplied to the spray unit during a time when the additive is not necessary.

A first rod electrode set has a first center axis, into which ions and air current are introduced. A second rod electrode set has a second center axis at a distance from the first center axis, from which the ions are discharged. A power supply applies voltages to the first rod electrode set and the second rod electrode set. The first rod electrode set and the second rod electrode set have a region where the sets overlap each other in the longitudinal direction, and form a single multipole ion guide by being combined to each other in the region. Different offset DC voltages are applied to the first rod electrode set and the second rod electrode set, respectively, and a DC potential for moving the ions to the second rod electrode set in the region is formed, the ions having been guided by the first rod electrode set.

Ion guide and mass spectrometer using same

An ion mobility separation device includes: an ion source that generates an ion; a pair of flat-plate electrodes having an introduction opening and a discharge opening for the ion generated by the ion source; a pump for causing the ion introduced via the introduction opening of the pair of flat-plate electrodes to travel toward the discharge opening; a voltage control unit that applies an asymmetric time-varying voltage and a direct-current voltage to the pair of flat-plate electrodes; a plurality of detectors disposed in a direction orthogonal to both an ion travel direction due to the pump and an applied direction of the asymmetric time-varying voltage; and a signal processing unit that processes a signal detected by the plurality of detectors. The voltage control unit performs a total transmission measurement involving application of the voltages to the pair of flat-plate electrodes so as to generate equal fields at least at two different points in the direction orthogonal to both the ion travel direction due to the pump and the applied direction of the asymmetric time-varying voltage. Compared to conventional technology, both high accuracy and high throughput are achieved in an asymmetric field application-type ion mobility separation device.

Ion mobility separation device

Growing community of inventors

Tachikawa, Japan

Hideki Hasegawa