Yazaki Corporation

Chugai Seiyaku Kabushiki Kaisha

Jsr Corporation

Jsr Life Sciences Corporation

Hideki Adachi

Naohiro Yabuta

Taro Imai

Koh Sato

Hidetomo Kitamura

Norihito Suzuki

Kou-ichi Jishage

Kiyoshi Habu

Yuji Migimatsu

Keiko Kasutani

Masakazu Hasegawa

Tetsuji Yamaguchi

Toshihiko Ohtomo

Hiraku Tanaka

Tsutomu Sawada

Tomoyoshi Kikkawa

Tsukasa Suzuki

Masakazu Umemura

Kunihiro Hattori

Katsu Yasui

Yasushi Shimonaka

Jun Amano

Kazuto Nakamura

Motoaki Mizuuchi

Minoru Hasegawa

Masahito Nakamura

Seiki Wakui

Kou-Ichi Jishage

A method of electric wire routing includes: routing an electric wire in an electric wire routing path which is provided in a case and has a concave shape in a cross-sectional view; and covering an upper portion of the electric wire routing path with a cover. A pair of guide pins are inserted into a through hole formed in a bottom portion of the electric wire routing path in the case from below to a position above a side wall portion which forms the electric wire routing path. The electric wire is passed between the guide pins. The cover is assembled to the upper portion of the electric wire routing path while the guide pins are pulled out from the through hole.

Method of electric wire routing

A connection structure for an electric wire includes an electric wire that has a conductor and an outer sheath covering the conductor; a bonding member that is made of a conductive metal material and is attached to the electric wire and; and a busbar that is made of a conductive metal material and on which the bonding member is overlapped and ultrasonically bonded with the conductor interposed between the busbar and the bonding member. The bonding member includes a crimping portion for crimping and fixing the electric wire.

Electric wire connection structure and connection method

The present invention relates to a method for assaying soluble GPC3 protein in a test sample, comprising using two different antibodies binding to different epitopes present in the N-terminal region of GPC3 protein.

Method for assaying soluble GPC3 protein

A rotating connector includes a movable housing and a steering angle sensor unit. The movable housing includes a cylindrical section through which a steering shaft penetrates and a main gear integrally molded with the movable housing on an outer circumferential surface of the cylindrical section along a rotation direction. The steering angle sensor unit includes a fixed-side housing into which the cylindrical section of the movable housing is inserted, a satellite gear which is provided in the fixed-side housing and meshed with the main gear, and a rotation angle detection unit which is provided in the fixed-side housing and detects rotation of the satellite gear.

Rotating connector

A case with connector includes a connector; a case body that has a cylindrical side wall portion and an end wall portion closing one end side of the side wall portion and forming an accommodation portion along with the side wall portion, the case body being formed by insert molding and integrated with the connector at the side wall portion; and an electrical wire that has an end connected to the connector and the other end projecting to the accommodation portion.

Case with connector and method of manufacturing case with connector

The present inventors obtained, from a phage library of human antibodies, an anti-mouse NR 10 neutralizing antibody-expressing BM095 clone that shows a strong proliferation-suppressing activity in an IL-31-dependent Ba/F3 cell proliferation assay system. When this anti-mouse NR 10 neutralizing antibody was administered to NC/Nga mice, a model of atopic dermatitis which is a mouse model of chronic dermatitis that arises as a result of repeated applications of picryl chloride, a mouse model of rheumatoid arthritis, and a mouse model of osteoarthritis, a significant effect of symptom suppression was observed. This revealed that the anti-NR 10 neutralizing antibody is indeed effective as a therapeutic agent for inflammatory diseases. In addition, the present inventors successfully obtained an anti-human NR 10 neutralizing antibody, providing extremely useful therapeutic agents with practical clinical applications.

Antibodies that bind to cytokine receptor NR10

A rotating connector includes a cable accommodation chamber formed between an outer case and an inner case in their radial direction, a flexible flat cable housed in the cable accommodation chamber, and multiple idlers housed in the cable accommodation chamber. The idlers are rotatably provided in a direction of an annular slidable member. The idlers are rotatable on their own axes. The flat cable is wound on an inner periphery of the outer case and an outer periphery of the inner case by way of a reversed portion of the flat cable. The flat cable is wound thereon in opposite directions. The idlers are pivotally supported by the slidable member so as to change a space between the idlers and the inner case and a space between the idlers and the outer case depending on winding of the flat cable.

Method of treating an inflammatory disease comprising administering an NR 10 antibody antagonist

A rotary connector, comprises an annular rotary body inserted outside a steering shaft and integrally rotated with a steering wheel, a rotator of a steering angle sensor inserted outside the steering shaft; and a tubular joint inserted outside the steering shaft and connecting the rotary body to the rotator; wherein the rotary body and the joint are connected together by a first universal joint, and the joint and the rotator are connected together by a second universal joint.

Rotary connector

A non-human animal that produces human tissue factor (TF) without substantially producing non-human animal tissue factor, said animal having a genome in which cDNA encoding human TF has been inserted upstream of the translation initiation codon for the non-human animal genomic TF gene.

Methods of using human tissue factor-producing knock-in mice

In the case when there are two objective biological activities, and the aim is to isolate a compound having at least one biological activity, the present inventors developed an assay method wherein a common detection marker is utilized for separately detecting the presence or absence of each of the biological activities. The present inventors discovered that a compound having at least one of two or more distinct biological activities can be efficiently and conveniently detected by simultaneously assaying at least one test sample or more by the above-mentioned method. Furthermore, for a test sample that proved to be positive by the detection method, they found that it is possible to efficiently and conveniently screen for a test sample having an objective specific biological activity by combining with a method wherein an individual activity of a test sample can be detected to specify the biological activity.

Screening methods for biologically active ligands

Knock-in non-human animal producing human tissue factor

A humanized antibody against tissue factor (TF), comprising: A: a humanized H chain comprising (1) a H chain V region comprising the H chain CDRs of a mouse monoclonal antibody against TF and the H chain FRs of a human antibody, and (2) the H chain C region of a human antibody; and B: a humanized L chain comprising (1) an L chain V region comprising the L chain CDRs of a mouse monoclonal antibody against TF and the L chain FRs of a human antibody, and (2) the L chain C region of a human antibody. After generating a humanized V region by grafting the CDRs of a mouse monoclonal antibody onto a human antibody, a humanized antibody having a higher activity is searched by replacing the FR of the above region with the corresponding FR of the human antibody having a high homology.

Humanized antibody against human tissue factor (TF) and process of production of the humanized antibody

A first cable conductor portion is placed on a first connector terminal. The first cable conductor portion is accommodated in a pressing recessed portion formed in an applying member. Ultrasonic vibration is applied to the first cable conductor portion and the first connector terminal and the first cable conductor portion and the first connector terminal are pressed, and thereby to be welded to each other.

Method of manufacturing connector for flat cable, connector for flat cable, and applying member for applying ultrasonic vibrations to be used for the same method

Growing community of inventors

Shizuoka, Japan

Hideki Adachi