Taiho Pharmaceutical Company Limited

Banyu Pharmaceutical Co. Ltd

Msd K.k.

Hidekazu Takahashi

Akio Kanatani

Morihiro Mitsuya

Nagaaki Sato

Tsuyoshi Nagase

Minoru Moriya

Hiroshi Sootome

Tetsuya Sugimoto

Shiho Ishikawa

Norio Masuko

Shunji Sakuraba

Hiroyuki Kishino

Toshihiro Sakamoto

Toshihiro Wada

Shigeru Tokita

Makoto Jitsuoka

Takashi Mizutani

Takao Suzuki

Minoru Kameda

A novel compound which has an excellent aurora A-selective inhibitory action and is useful as an orally administrable anticancer agent is provided. Also, a novel agent for potentiation of anti-tumor effect of microtubule agonists, which include a taxane anticancer agent, and a combination therapy are provided. A piperidine compound represented by a general formula (I) or a salt thereof: 

Piperidine compound or salt thereof

[PROBLEMS] To provide a compound useful as an agent for the treatment of circulatory diseases, nervous system diseases, metabolic diseases, reproductive system diseases, and digestive tract diseases. [MEANS FOR SOLVING PROBLEMS] The compound, which is for use as an active ingredient, is represented by the formula (I): [wherein Rrepresents optionally halogenated Calkyl, etc.; Rrepresents, e.g., a group represented by the formula (II-1) or (II-4) (wherein W represents Calkylene, etc. and R represents Calkyl, etc.); Rrepresents hydrogen, Calkyl, etc.; X represents &#x2014;O&#x2014;, &#x2014;NH&#x2014;, etc.; and Y, Y, Y, and Yeach independently represents &#x2014;CH&#x2014;, &#x2014;N&#x2014;, etc.].

Benzoxazinone derivative

Disclosed is a substance having an antagonistic effect on the binding of histamine to a histamine H3 receptor or an inhibitory effect on the activity which a histamine H3 receptor constantly exhibits. A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof; (I) wherein R1 represents a phenyl group which may be substituted or the like and R2 represents a cyano group which may be substituted or the like, or R1 and R2 together form an aliphatic heterocylic ring which may be substituted; R3 represents a group represented by the formula (II-1) below; and all of X1 to X4 represent a carbon atom or the like: (II-1) where R4 and R5 represent a lower alkyl group or the like; and m1 represents an integer of 2 to 4.

Piperidine derivative

The present invention provides an imidazopyridine compound represented by formula (I), wherein Rand Reach independently represent a Calkyl group et al; Rand Reach independently represent a hydrogen atom, a methyl et al; Aris a divalent substituent representing a monocyclic or bicyclic, 3- to 8-membered aromatic or aliphatic heterocyclic group et al; Arrepresents an aromatic carbocyclic group, or an aromatic heterocyclic group; W represents &#x2014;(CH)et al, and m indicates an integer of from 0 to 10. This compound acts as a melanin concentrating hormone receptor antagonist, and is useful as treating agents for obesity.

Imidazopyridine compound

The invention provides imidazopyridine derivatives represented by the general formula [I] [in which Rand Rmay be the same or different and stand for Calkyl or the like, Rand Rstand for hydrogen atom, methyl group or the like, W stands for mono- or bi-cyclic 3- to 8-membered aromatic or aliphatic heterocycle or the like, and Ar stands for optionally substituted aromatic heterocycle or the like]. These compounds act as melanin-concentrating hormone receptor antagonist and are useful as medicines for central nervous system disorders, cardiovascular system disorders and metabolic disorders.

Imidazopyridine derivatives

Growing community of inventors

Tsukuba, Japan

Hidekazu Takahashi