Takeda Chemical Industries, Inc.

Hidekazu Sawada

Takashi Suzuki

Mitsuru Shiraishi

Masanori Baba

Naoyuki Kanzaki

Osamu Nishimura

Hiroyuki Kimura

Yoshio Aramaki

Ken-ichi Kuroshima

Shuji Hinuma

Junichi Sakamoto

Haruo Onda

Kazuaki Kitano

Shoichi Ohkubo

Tomohiro Kawamoto

Kazuyoshi Katamoto

Junya Okada

Tsunetomo Asai

Keiji Iwamoto

The present invention provides a novel protein and its use. The protein or its salt, the partial protein, its amide or ester, or salts, and DNA encoding the same can be employed for obtaining antibodies and antisera, constructing the expression system of the protein of the present invention, for constructing the assay system for the GABA transporter activity and screen medicament candidate compounds using the expression system, for making drug design based on the steric structure of GABA transporters, as agents for producing probes or PCR primers in gene diagnosis, for preparing transgenic animals or as pharmaceuticals for the prevention/treatment of genetic disorders.

GABA transporter protein and DNA thereof

Sodium bicarbonate cotransporter protein

This invention is to provide a pharmaceutical composition for antagonizing CCR5 which comprises a compound of the formula:

Pharmaceutical composition for antagonizing CCR5 comprising anilide derivative

Disclosed are CHO cells which are capable of continued production of human LH-RH receptor proteins, or cell membrane fractions thereof; recombinant human LH-RH receptor proteins or partial peptides thereof; methods for screening compounds which have affinity for an LH-RH receptor by contacting the compound with the CHO cells or the cell membrane fractions thereof, or the recombinant human LH-RH receptor proteins or the partial peptides thereof; kits for screening them; the compounds which have affinity for the LH-RH receptor obtained by methods for the screening or kits for the screening; and pharmaceutical compositions containing the compound, thereby being able to early provide prophylactic or therapeutic compositions, for example, for prostate cancer, uterine cancer, breast cancer, a pituitary tumor, endometriosis, hysteromyoma or precocious puberty. They are also useful as a pregnancy controlling composition such as contraceptive or a menstrual cycle controlling composition.

CHO cells that express human LH-RH receptor

Disclosed are (1) a hybridoma carrying a vector for expressing a fibroblast growth factor (FGF) protein gene; (2) a method for producing the hybridoma of (1) which comprises transforming a hybridoma with the vector for expressing the FGF protein gene; and (3) a method for producing a biologically active substance which comprises cultivating in a culture medium the hybridoma obtained by the method of (2) using a hybridoma producing a biologically active substance other than the FGF protein, producing the FGF protein and producing and accumulating the biologically active substance in a culture, and recovering the biologically active substance, whereby the biologically active substance can be efficiently produced and recovered using the serum-free medium, which is advantageous for industrial production and very useful for an improvement in the breeding of the hybridoma.

Fibroblast growth factor gene transformed hybridoma and enhanced

Yield of lankacidin antibiotics is enhanced by incorporating cyclodextrin into a culture medium where a microorganism capable of producing lankacidin is cultivated.

Lankacidins production

A method for producing mildiomycin in a commercial quantity and at low cost by cultivating a mildiomycin-producing microorganism belonging to Actinomycetes in a culture medium containing an N-methyl compound in an amount of at least 3 mM to have mildiomycin elaborated and accumulated in the culture broth.

Method for producing mildiomycin

Mildiomycin analogs and a method of production

Growing community of inventors

Osaka, Japan

Hidekazu Sawada