Nard Institute, Ltd.

Osaka University

Hamamatsu-photonics K.k.

Hidekazu Nakao

Tokutaro Ogata

Hideo Tsukada

Yoshikatsu Kanai

Shingo Nishiyama

Tatsuhiro Kobashi

Shushi Nagamori

Takeru Kitashoji

Yumi Nakamasu

Junichi Hoshino

Naoki Miyashita

Yoshikazu Yamamoto

A compound having a structure represented by the general formula (I): (wherein n is 0 or 1;Rrepresents a hydrogen atom (only if n=0), a halogen atom, a C1-C6 alkyl group, a C1-C6 haloalkyl group, an optionally substituted amino group, an optionally substituted phenyl group, a C1-C6 alkylthio group, a C1-C6 alkoxy group, a C1-C6 haloalkoxy group or a C7-C12 aralkyloxy group;Rrepresents &#x2014;(CH)&#x2014;[O(CH)]&#x2014;X (wherein X is a halogen atom, p is an integer of 1 to 6, q is an integer of 1 to 4, and r is an integer of 0 to 4);Rrepresents a hydrogen atom, a C1-C6 alkyl group, a C7-C16 aralkyl group or a C6-C14 aryl group; andRrepresents a hydrogen atom or a C1-C6 alkyl group), or a pharmaceutically acceptable salt thereof excels FAMT in terms of the tendency to accumulate intensively in cancer, the affinity for LAT1 and the selectivity for cancer, and can be labeled using an automated synthesizer in clinical settings, and therefore is useful as a highly versatile PET imaging agent.

Aromatic amino acid derivative and positron emission topography (PET) probe using the same

The present invention provides a compound represented by formula (I), wherein in formula (I), Rrepresents CH, F, (CH)&#x2014;F, NH&#x2014;(CH)&#x2014;F, O&#x2014;(CH)&#x2014;F or S&#x2014;(CH)&#x2014;F, and n represents an integer of 1 to 3. 

Compound suitable for detection of vesicular acetylcholine transporter

The objective of the present invention is to provide a tyrosine derivative which is useful as a melatonin MTreceptor antagonist, and a method for producing a specific tyrosine derivative with high yield by efficiently introducing an iodine atom at the para position of the phenolic hydroxy group in the benzene ring of tyrosine with good regioselectivity. The tyrosine derivative of the present invention is characterized in being represented by the following formula (I): wherein Ris a protective group of the amino group and the like; Ris a protective group of the carboxy group and the like; Ris a hydrogen atom and the like; Ris a halogen atom and the like; A is &#x2014;(CH)&#x2014;[Z(CH)]&#x2014;; X is a leaving group.

Tyrosine derivative and method for producing tyrosine derivative

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Amagasaki, Japan

Hidekazu Nakao