Toa Eiyo Ltd.

Hidekazu Masaki

Atsuo Takahashi

Masayuki Kageyama

Takeshi Hasegawa

Shin-ichi Kazayama

Fumiya Yoneyama

Hideki Yamada

Shinji Takai

Mizuo Miyazaki

Yusuke Mizuno

Tetsuo Kuze

Takahiro Morita

Akira Tatsui

Shoji Satoh

Yujiro Uchino

Koichi Takayanagi

Ryutaro Shimono

Tomoyuki Nagayama

Hiroshi Takasugi

Yoichi Iwasaki

Provided is a novel compound having an excellent suppression effect against arrhythmia including atrial fibrillation and being useful as a pharmaceutical product without antiviral effect. Disclosed is a compound represented by the following General Formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof (in the formula, the dotted line portion represents a single bond or a double bond; Rrepresents an optionally substituted Calkyl group; Q represents an oxygen atom, a sulfur atom, or NR; Rrepresents &#x2014;(C&#x2550;O)&#x2014;R, &#x2014;CHRR, or &#x2014;CHOR; and Rand R, which may be identical or different, each represent an amino group, an azide group, or &#x2014;X&#x2014;R, with the proviso that any one of Rand Ris an amino group). 

Cyclic hydrocarbon compound

Provided is a compound which is useful as a prophylactic or therapeutic agent for various diseases in which T-type calcium channels are involved, such as hypertension, arrhythmia, pain and cancers, the compound having antagonistic activity against T-type calcium channels, being highly stable in the body and having low risk of, for example, genotoxicity. Disclosed is a compound represented by the following general formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof: 

Substituted tropane derivatives

Provided is a novel compound which shows an antagonistic effect against T-type calcium channels, and is useful as a pharmaceutical product. A compound represented by general formula (I), and a pharmaceutical agent containing the same, are disclosed: wherein n represents the number of nitrogen atoms contained in the 6-membered fused aromatic ring, and is 0, 1 or 2; p represents the number of nitrogen atoms contained in the 6-membered aromatic ring, and is 0 or 1; X represents an oxygen atom, &#x2014;SO&#x2014; or &#x2014;N(R)&#x2014;; and Rto Reach represents a hydrogen atom or other substituents.

Fused imidazole derivative

The present invention relates to an N-substituted benzothiophenesulfonamide derivative or a pharmaceutically acceptable salt thereof and applications thereof. Furthermore, it provides an agent for preventing or treating cardiac or circulatory disease and so on caused by abnormal increase of production of angiotensin II or endothelin I based on chymase activity, or by activation of mast cell, and an agent for preventing adhesion after surgery, wherein the agent has a selective inhibitory action on chymase.

N-substituted benzothiophenesulfonamide derivatives

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Saitama, Japan

Hidekazu Masaki