Shionogi Company Limited

Hidekazu Haraguchi

Akira Kato

Kazuo Ueda

Naotake Kobayashi

Akihiro Hori

Naohiro Itoh

Gaku Sakaguchi

Ken Yasui

Shinji Suzuki

Akira Yukimasa

Yasuhiko Kanda

Yuji Koriyama

Yuuji Kooriyama

A composition having BACE 1 inhibitory activity containing a compound represented by the formula (I): 

Aminodihydrothiazine derivatives

A pharmaceutical composition for treating Alzheimer's disease containing a compound represented by the general formula (I): 

Pharmaceutical composition for treating alzheimer's disease

A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): 

A pharmaceutical composition for treating Alzheimer's disease containing a compound represented by the general formula (I); wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group;

Pharmaceutical composition for treating Alzheimer's disease

A composition having BACE 1 inhibitory activity containing a compound represented by the formula (I): wherein ring A is an optionally substituted heterocyclic group;E is lower alkylene;X is S;Ris a hydrogen atom or lower alkyl;R, R, R, R, Rand Ris each independently a hydrogen atom, halogen, or hydroxy etc.;n and m are each independently an integer of 0 to 3;n+m is an integer of 0 to 3;Ris a hydrogen atom or substituted lower alkyl;or its pharmaceutically acceptable salt thereof.

A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group;

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Osaka, Japan

Hidekazu Haraguchi